{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:04:54Z","timestamp":1782536694192,"version":"3.54.5"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:p>Background: Digital cognitive tests offer several potential advantages over established paper-pencil tests but have not yet been fully evaluated for the clinical evaluation of mild cognitive impairment. Objective: The NeuroCognitive Performance Test (NCPT) is a web-based, self-directed, modular battery intended for repeated assessments of multiple cognitive domains. Our objective was to examine its relationship with the Alzheimer\u2019s Disease Assessment Scale-Cognition Subscale (ADAS-Cog) and Mini-Mental State Examination (MMSE) as well as with established paper-pencil tests of cognition and daily functioning in mild cognitive impairment (MCI). Methods: We used Spearman correlations, regressions and principal components analysis followed by a factor analysis (varimax rotated) to examine our objectives. Results: In MCI subjects, the NCPT composite is significantly correlated with both a composite measure of established tests (r\u200a=\u200a0.78, p\u200a&lt;\u200a0.0001) as well as with the ADAS-Cog (r\u200a=\u200a\u20130.55, p\u200a&lt;\u200a0.0001). Both NCPT and paper-pencil test batteries had a similar factor structure that included a large \u201cg\u201d component with a high eigenvalue. The correlation for the analogous tests (e.g., Trails A and B, learning memory tests) were significant (p\u200a&lt;\u200a0.0001). Further, both the NCPT and established tests significantly (p\u200a&lt;\u200a0.0001) predicted the University of California San Diego Performance-Based Skills Assessment and Functional Activities Questionnaire, measures of daily functioning. Conclusion: The NCPT, a web-based, self-directed, computerized test, shows high concurrent validity with established tests and hence offers promise for use as a research or clinical tool in MCI. Despite limitations such as a relatively small sample, absence of control group and cross-sectional nature, these findings are consistent with the growing literature on the promise of self-directed, web-based cognitive assessments for MCI.<\/jats:p>","DOI":"10.3233\/jad-220015","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T11:48:52Z","timestamp":1645184932000},"page":"1131-1136","source":"Crossref","is-referenced-by-count":6,"title":["Validity of the Web-Based, Self-Directed, NeuroCognitive Performance Test in Mild Cognitive Impairment"],"prefix":"10.1177","volume":"86","author":[{"given":"P. Murali","family":"Doraiswamy","sequence":"first","affiliation":[{"name":"Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA"},{"name":"Duke Institute for Brain Sciences, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry E.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra R.","family":"Linares","sequence":"additional","affiliation":[{"name":"Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaora","family":"Nwosu","sequence":"additional","affiliation":[{"name":"Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izael","family":"Nino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Ndouli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hellegers","sequence":"additional","affiliation":[{"name":"Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Michael","sequence":"additional","affiliation":[{"name":"Duke Institute for Brain Sciences, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Petrella","sequence":"additional","affiliation":[{"name":"Department of Radiology, Duke University Medical Center, 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