{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:55:00Z","timestamp":1783641300942,"version":"3.55.0"},"reference-count":86,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Background: Investigation of neural response patterns along the entire network of functionally defined object recognition ventral stream regions in Alzheimer\u2019s disease (AD) is surprisingly lacking. Objective: We aimed to investigate putative functional reorganization along a wide-ranging network of known regions in the ventral visual stream in mild AD. Methods: Overall we investigated 6 regions of interest (5 of which were not investigated before), in 19 AD patients and 19 controls, in both hemispheres along the ventral visual stream: Fusiform Face Area, Fusiform Body Area, Extrastriate Body Area, Lateral Occipital Cortex, Parahippocampal Place Area, and Visual Word Form Area, while assessing object recognition performance. Results: We found group differences in dprime measures for all object categories, corroborating generalized deficits in object recognition. Concerning neural responses, we found region dependent group differences respecting a priori expected Hemispheric asymmetries. Patients showed significantly decreased BOLD responses in the right hemisphere-biased Fusiform Body Area, and lower left hemisphere responses in the Visual Word Form Area (with a priori known left hemispheric bias), consistent with deficits in body shape and word\/pseudoword processing deficits. This hemispheric dominance related effects were preserved when controlling for performance differences. Whole brain analysis during the recognition task showed enhanced activity in AD group of left dorsolateral prefrontal cortex, left cingulate gyrus, and in the posterior cingulate cortex\u2014 a hotspot of amyloid-\u03b2 accumulation. Conclusion: These findings demonstrate region dependent respecting hemispheric dominance patterns activation changes in independently localized selective regions in mild AD, accompanied by putative compensatory activity of frontal and cingular networks.<\/jats:p>","DOI":"10.3233\/jad-220055","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:55:40Z","timestamp":1671540940000},"page":"1151-1164","source":"Crossref","is-referenced-by-count":8,"title":["Hemispheric Patterns of Recruitment of Object Processing Regions in Early Alzheimer\u2019s Disease: A Study Along the Entire Ventral Stream"],"prefix":"10.1177","volume":"91","author":[{"given":"N\u00e1dia S.","family":"Can\u00e1rio","sequence":"first","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edlia P.","family":"Jorge","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel J.","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel S.","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220055_ref1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3233\/JAD-161028","article-title":"Radiological-pathological correlation in Alzheimer\u2019s disease:Systematic review of antemortem magnetic resonance imaging findings","volume":"57","author":"Dallaire-Th\u00e9roux","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-220055_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jmf.2017.0093","article-title":"Alzheimer\u2019s disease\u2014 current status and future directions","volume":"20","author":"Bhardwaj","year":"2017","journal-title":"J Med 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