{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:18:30Z","timestamp":1787725110539,"version":"build-2784847793"},"reference-count":75,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies of hippocampal function and volume related to episodic memory deficits in patients with amnestic mild cognitive impairment (aMCI) have produced mixed results including increased or decreased activity and volume. However, most of them have not included biomarkers, such as amyloid-\u03b2 (A\u03b2) deposition which is the hallmark for early identification of the Alzheimer\u2019s disease continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated the role of A\u03b2 deposition, functional hippocampal activity and structural volume in aMCI patients and healthy elderly controls (HC) using a new functional MRI (fMRI) ecological episodic memory task.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-six older adults were included, among them A\u03b2 PET PIB positive (PIB+) aMCI (N\u200a=\u200a17), A\u03b2 PET PIB negative (PIB\u2013) aMCI (N\u200a=\u200a15), and HC (N\u200a=\u200a14). Hippocampal volume and function were analyzed using Freesurfer v6.0 and FSL for news headlines episodic memory fMRI task, and logistic regression for group classification in conjunction with episodic memory task and traditional neuropsychological tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The aMCI PIB+ and PIB\u2013patients showed significantly worse performance in relation to HC in most traditional neuropsychological tests and within group difference only on story recall and the ecological episodic memory fMRI task delayed recall. The classification model reached a significant accuracy (78%) and the classification pattern characterizing the PIB+ included decreased left hippocampal function and volume, increased right hippocampal function and volume, and worse episodic memory performance differing from PIB\u2013which showed increased left hippocampus volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The main findings showed differential neural correlates, hippocampal volume and function during episodic memory in aMCI patients with the presence of A\u03b2 deposition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-220100","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T12:28:56Z","timestamp":1658233736000},"page":"181-192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Episodic Memory, Hippocampal Volume, and Function for Classification of Mild Cognitive Impairment Patients Regarding Amyloid Pathology"],"prefix":"10.1177","volume":"89","author":[{"given":"Eliane Correa","family":"Miotto","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]},{"name":"Institute of Radiology","place":["Brazil"]},{"name":"Universidade de Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Maria Dozzi","family":"Brucki","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos T.","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R.","family":"Baz\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Radiology","place":["Brazil"]},{"name":"Universidade de Sao Paulo","place":["Brazil"]},{"name":"Hospital Israelita Albert Einstein","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geise Aline de Almeida","family":"Silva","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Gra\u00e7a M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Institute of Radiology","place":["Brazil"]},{"name":"Universidade de Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Squarzoni","family":"da Silveira","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele de Paula","family":"Faria","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Martins","family":"Coutinho","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo","family":"Busatto Filho","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Nitrini","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000313"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22927"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_3_2_11_2","volume-title":"Methods of Behavior Analysis in Neuroscience","author":"Bryan KJ","year":"2009","unstructured":"BryanKJ, LeeH, PerryG, SmithMA, CasadesusG (2009) Transgenic mouse models of alzheimer\u2019s disease: Behavioral testing and considerations. 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