{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:48Z","timestamp":1787025888779,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:p>Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer\u2019s disease (AD). It is time to focus on more promising options, e.g., infection, low dose radiation, and atherosclerosis. The relevance of the latter in managing AD has fluctuated from being significant to insignificant. Current methodologies for detecting cerebral atherosclerosis reflect advanced changes in only major arteries. In contrast, 18F-sodium fluoride PET imaging assessing early-stage cerebral atherosclerosis regionally or in the entire vascular bed may provide new insight in this age-related process in dementia.<\/jats:p>","DOI":"10.3233\/jad-220190","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T13:07:18Z","timestamp":1652792838000},"page":"455-458","source":"Crossref","is-referenced-by-count":9,"title":["Alzheimer\u2019s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects\u2014Atherosclerosis for a Start"],"prefix":"10.1177","volume":"88","author":[{"given":"Poul F.","family":"H\u00f8ilund-Carlsen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-7420","authenticated-orcid":false,"given":"Mona-Elisabeth","family":"Revheim","sequence":"additional","affiliation":[{"name":"Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abass","family":"Alavi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220190_ref2","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3233\/JAD-215275","article-title":"Aducanumab (marketed as Aduhelm) approval is likely based on misinterpretation of PET imaging data","volume":"84","author":"H\u00f8ilund-Carlsen","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-220190_ref3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JAD-210383","article-title":"New IDEAS Amyloid Imaging 2021 Study: Running in place with ineffective anti-amyloid treatments for Alzheimer\u2019s disease patients","volume":"82","author":"Barrio","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-220190_ref5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/vaccines9060679","article-title":"Overwhelming evidence for a major role for herpes simplex virus type 1 (HSV1) in Alzheimer\u2019s disease (AD); 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