{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:00:18Z","timestamp":1777395618256,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:p>Background: Mid-regional pro-adrenomedullin (MR-proADM) is a novel biomarker for cognitive decline based on its association with cerebral small vessel disease (SVD). Cerebral microbleeds (MBs) are characteristic of SVD; however, a direct association between MR-proADM and MBs has not been explored. Objective: We aimed to examine whether circulating levels of MR-proADM are associated with the identification of MBs by brain magnetic resonance imaging (MRI) and whether this association could be linked with cognitive impairment. Methods: In total, 214 participants (mean age: 75.9 years) without history of cerebral infarction or dementia were prospectively enrolled. All participants underwent brain MRI, higher cognitive function testing, blood biochemistry evaluation, lifestyle examination, and blood MR-proADM measurement using a time-resolved amplified cryptate emission technology assay. For between-group comparisons, the participants were divided into two groups according to whether their levels of MR-proADM were normal (&lt;\u200a0.65\u200anmol\/L) or high (\u22650.65\u200anmol\/L). Results: The mean MR-proADM level was 0.515\u00b10.127\u200anmol\/L. There were significant between-group differences in age, hypertension, and HbA1c levels (p\u200a&lt;\u200a0.05). In the high MR-proADM group, the MR-proADM level was associated with the identification of MBs on brain MR images and indications of mild cognitive impairment (MCI). In participants with \u22653 MBs and MCI, high MR-proADM levels remained a risk factor after multivariate adjustment (OR: 2.94; p\u200a&lt;\u200a0.05). Conclusion: High levels of MR-proADM may be a surrogate marker for the early detection of cognitive decline associated with the formation of cerebral MBs. This marker would be valuable during routine clinical examinations of geriatric patients.<\/jats:p>","DOI":"10.3233\/jad-220195","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T12:40:01Z","timestamp":1654605601000},"page":"731-741","source":"Crossref","is-referenced-by-count":6,"title":["Association Between Cerebral Microbleeds and Circulating Levels of Mid-Regional Pro-Adrenomedullin"],"prefix":"10.1177","volume":"88","author":[{"given":"Nagato","family":"Kuriyama","sequence":"first","affiliation":[{"name":"Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan"},{"name":"Department of Social Health Medicine, Shizuoka Graduate University of Public Health, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhide","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Epidemiology for Community Health and Medicine, Kyoto 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