{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:18:32Z","timestamp":1782512312635,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early detection of amyloid-\u03b2 (A\u03b2) aggregates is a critical step to improve the treatment of Alzheimer\u2019s disease (AD) because neuronal damage by the A\u03b2 aggregates occurs before clinical symptoms are apparent. We have previously shown that luminescent conjugated oligothiophenes (LCOs), which are highly specific towards protein aggregates of A\u03b2, can be used to fluorescently label amyloid plaque in living rodents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      We hypothesize that the LCO can be used to target gadolinium to the amyloid plaque and hence make the plaque detectable by T\n                      <jats:sub>1<\/jats:sub>\n                      -weighted magnetic resonance imaging (MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A novel LCO-gadolinium construct was synthesized to selectively bind to A\u03b2 plaques and give contrast in conventional T\n                      <jats:sub>1<\/jats:sub>\n                      -weighted MR images after intravenous injection in Tg-APPSwe mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that mice with high plaque-burden could be identified using the LCO-Gd constructs by conventional MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study shows that MR imaging of amyloid plaques is challenging but feasible, and hence contrast-mediated MR imaging could be a valuable tool for early AD detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-220198","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T11:55:33Z","timestamp":1680609333000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Contrast Enhanced Magnetic Resonance Imaging of Amyloid-\u03b2 Plaques in a Murine Alzheimer\u2019s Disease Model"],"prefix":"10.1177","volume":"93","author":[{"given":"Einar","family":"Sulheim","sequence":"first","affiliation":[{"name":"Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Biotechnology and Nanomedicine, SINTEF AS, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Wider\u00d8e","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"B\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Biology, Division of Chemistry, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Peter R.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Biology, Division of Chemistry, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Biology, Division of Chemistry, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars N.G.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oslo and Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina de Lange","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Physics, Norwegian University of Science and Technology, Trondheim, 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