{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:10:26Z","timestamp":1794373826068,"version":"4.9.0"},"reference-count":105,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,10,25]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) includes progressive symptoms spread along a continuum of preclinical and clinical stages. Although numerous studies uncovered the neuro-cognitive changes of AD, very little is known on the natural history of brain lesions and modifications of brain networks in elderly cognitively-healthy memory complainers at risk of AD for carrying pathophysiological biomarkers (amyloidopathy and tauopathy). Objective: We analyzed resting-state electroencephalography (EEG) of 318 cognitively-healthy subjective memory complainers from the INSIGHT-preAD cohort at the time of their first visit (M0) and two-years later (M24). Methods: Using 18F-florbetapir PET-scanner, subjects were stratified between amyloid negative (A\u2013; n\u200a=\u200a230) and positive (A+; n\u200a=\u200a88) groups. Differences between A+ and A\u2013 were estimated at source-level in each band-power of the EEG spectrum. Results: At M0, we found an increase of theta power in the mid-frontal cortex in A+ compared to A\u2013. No significant association was found between mid-frontal theta and the individuals\u2019 cognitive performance. At M24, theta power increased in A+ relative to A\u2013 individuals in the posterior cingulate cortex and the pre-cuneus. Alpha band revealed a peculiar decremental trend in posterior brain regions in the A+ relative to the A\u2013 group only at M24. Theta power increase over the mid-frontal and mid-posterior cortices suggests an hypoactivation of the default-mode network in the A+ individuals and a non-linear longitudinal progression at M24. Conclusion: We provide the first source-level longitudinal evidence on the impact of brain amyloidosis on the EEG dynamics of a large-scale, monocentric cohort of elderly individuals at-risk for AD.<\/jats:p>","DOI":"10.3233\/jad-220204","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T11:26:30Z","timestamp":1662117990000},"page":"69-84","source":"Crossref","is-referenced-by-count":28,"title":["Theta Band-Power Shapes Amyloid-Driven Longitudinal EEG Changes in Elderly Subjective Memory Complainers At-Risk for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"90","author":[{"given":"Giuseppe","family":"Spinelli","sequence":"first","affiliation":[{"name":"Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Sorbonne Universit\u00e9, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Centre MEG-EEG, CENIR, Paris, France"},{"name":"Institute of Memory and Alzheimer\u2019s Disease (IM2A), Department of Neurology, AP-HP, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the INSIGHT-preAD Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hovagim","family":"Bakardjian","sequence":"additional","affiliation":[{"name":"Institute of Memory and Alzheimer\u2019s Disease (IM2A), Department of Neurology, AP-HP, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Schwartz","sequence":"additional","affiliation":[{"name":"CERMEP-Imagerie du Vivant, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Potier","sequence":"additional","affiliation":[{"name":"Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Sorbonne Universit\u00e9, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Centre MEG-EEG, CENIR, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Habert","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, Laboratoire d\u2019Imagerie Biom\u00e9dicale, Sorbonne Universit\u00e9, Paris, France"},{"name":"AP-HP, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, M\u00e9decine Nucl\u00e9aire, Paris, France"},{"name":"Centre d\u2019Acquisition et Traitement des Images (CATI), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Levy","sequence":"additional","affiliation":[{"name":"Institute of Memory and Alzheimer\u2019s Disease (IM2A), Department of Neurology, AP-HP, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dubois","sequence":"additional","affiliation":[{"name":"Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Sorbonne Universit\u00e9, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Centre MEG-EEG, CENIR, Paris, France"},{"name":"Institute of Memory and Alzheimer\u2019s Disease (IM2A), Department of Neurology, AP-HP, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"George","sequence":"additional","affiliation":[{"name":"Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Sorbonne Universit\u00e9, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Centre MEG-EEG, CENIR, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220204_ref1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-220204_ref2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-220204_ref3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s disease drug-development pipeline: Few candidates, frequent failures","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-220204_ref4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1017\/S1355617702813248","article-title":"What is cognitive reserve? 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