{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T06:53:49Z","timestamp":1781420029105,"version":"3.54.1"},"reference-count":63,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,9,27]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-\u03b2 protein (A\u03b2) within brain blood vessels that develops in elderly people and Alzheimer\u2019s disease (AD) patients. Therefore, the investigation of biomarkers able to differentiate CAA patients from AD patients and healthy controls (HC) is of great interest, in particular in peripheral fluids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The current study aimed to detect the neurodegenerative disease (ND)-related protein (i.e., A\u03b2\n                      <jats:sub>1-40<\/jats:sub>\n                      , A\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      , tau, and \u03b1-synuclein) levels in both red blood cells (RBCs) and plasma of CAA patients and HC, evaluating their role as putative peripheral biomarkers for CAA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>For this purpose, the proteins\u2019 concentration was quantified in RBCs and plasma by homemade immunoenzymatic assays in an exploratory cohort of 20 CAA patients and 20 HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results highlighted a significant increase of A\u03b2\n                      <jats:sub>1-40<\/jats:sub>\n                      and \u03b1-synuclein concentrations in both RBCs and plasma of CAA patients, while higher A\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      and t-tau levels were detected only in RBCs of CAA individuals compared to HC. Moreover, A\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>1-40<\/jats:sub>\n                      ratio increased in RBCs and decreased in plasma of CAA patients. The role of these proteins as candidate peripheral biomarkers easily measurable with a blood sample in CAA needs to be confirmed in larger studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In conclusion, we provide evidence concerning the possible use of blood biomarkers for contributing to CAA diagnosis and differentiation from other NDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-220216","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T11:02:41Z","timestamp":1660042961000},"page":"1039-1049","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Amyloid-\u03b2, Tau, and \u03b1-Synuclein Proteins as Putative Blood Biomarkers in Patients with Cerebral Amyloid 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