{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:33:01Z","timestamp":1778185981794,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,5,30]]},"abstract":"<jats:p>Background: Depletion of blood-derived progenitor cells, including so called \u201cearly endothelial progenitor cells\u201d, has been observed in individuals with early stage Alzheimer\u2019s disease relative to matched older control subjects. These findings could implicate the loss of angiogenic support from hematopoietic progenitors or endothelial progenitors in cognitive dysfunction. Objective: To investigate links between progenitor cell proliferation and mild levels of cognitive dysfunction. Methods: We conducted in vitro studies of blood-derived progenitor cells using blood samples from sixty-five older adults who were free of stroke or dementia. Peripheral blood mononuclear cells from venous blood samples were cultured in CFU-Hill media and the number of colony forming units were counted after 5 days in vitro. Neuropsychological testing was administered to all participants. Results: Fewer colony forming units were observed in samples from older adults with a Clinical Dementia Rating global score of 0.5 versus 0. Older adults whose samples developed fewer colony forming units exhibited worse performance on neuropsychological measures of memory, executive functioning, and language ability. Conclusion: These data suggest blood progenitors may represent a vascular resilience marker related to cognitive dysfunction in older adults.<\/jats:p>","DOI":"10.3233\/jad-220269","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T12:22:51Z","timestamp":1683289371000},"page":"1041-1050","source":"Crossref","is-referenced-by-count":4,"title":["Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience?"],"prefix":"10.1177","volume":"93","author":[{"given":"Anisa J.","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee","family":"Gaubert","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Yew","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean K.","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"Blanken","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubir","family":"Dutt","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Southern California, Los Angeles, CA, USA"},{"name":"Davis School of Gerontology, University of 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