{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:05:47Z","timestamp":1777395947150,"version":"3.51.4"},"reference-count":77,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:p>Background: Lesbian and gay older adults have health disparities that are risk factors for Alzheimer\u2019s disease, yet little is known about the neurocognitive aging of sexual minority groups. Objective: To explore cross-sectional and longitudinal dementia outcomes for adults in same-sex relationships (SSR) and those in mixed-sex relationships (MSR). Methods: This prospective observational study utilized data from the National Alzheimer\u2019s Coordinating Center Uniform Data Set (NACC UDS) collected from contributing Alzheimer\u2019s Disease Research Centers. Participants were adults aged 55+ years at baseline with at least two visits in NACC UDS (from September 2005 to March 2021) who had a spouse, partner, or companion as a co-participant. Outcome measures included CDR\u00ae Dementia Staging Instrument, NACC UDS neuropsychological testing, and the Functional Activities Questionnaire. Multivariable linear mixed-effects models accounted for center clustering and repeated measures by individual. Results: Both MSR and SSR groups experienced cognitive decline regardless of baseline diagnosis. In general, MSR and SSR groups did not differ statistically on cross-sectional or longitudinal estimates of functioning, dementia severity, or neuropsychological testing, with two primary exceptions. People in SSR with mild cognitive impairment showed less functional impairment at baseline (FAQ M\u200a=\u200a2.61, SD\u200a=\u200a3.18 vs. M\u200a=\u200a3.97, SD\u200a=\u200a4.53, respectively; p\u200a&lt;\u200a0.01). The SSR group with dementia had less steep decline in attention\/working memory (\u03b2 estimates\u200a=\u200a\u20130.10 versus \u20130.18; p\u200a&lt;\u200a0.01). Conclusion: Participants in SSR did not show cognitive health disparities consistent with a minority stress model. Additional research into protective factors is warranted.<\/jats:p>","DOI":"10.3233\/jad-220309","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T12:48:37Z","timestamp":1674564517000},"page":"109-128","source":"Crossref","is-referenced-by-count":5,"title":["Cognitive Aging with Dementia, Mild Cognitive Impairment, or No Impairment: A Comparison of Same- and Mixed-Sex Couples"],"prefix":"10.1177","volume":"92","author":[{"given":"Anthony N.","family":"Correro II","sequence":"first","affiliation":[{"name":"Mental Health Service, VA Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan Health, Ann Arbor, MI, USA"},{"name":"Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Gauthreaux","sequence":"additional","affiliation":[{"name":"National Alzheimer\u2019s Coordinating Center, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Perales-Puchalt","sequence":"additional","affiliation":[{"name":"University of Kansas, Alzheimer\u2019s Disease Research Center, Fairway, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"National Alzheimer\u2019s Coordinating Center, University of Washington, Seattle, WA, USA"},{"name":"Department of Statistics, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwun C.G.","family":"Chan","sequence":"additional","affiliation":[{"name":"National Alzheimer\u2019s Coordinating Center, University of Washington, Seattle, WA, USA"},{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.","family":"Kukull","sequence":"additional","affiliation":[{"name":"National Alzheimer\u2019s Coordinating Center, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Flatt","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Health, School of Public Health, University of Nevada, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220309_ref1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1037\/0033-2909.129.5.674","article-title":"Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence","volume":"129","author":"Meyer","year":"2003","journal-title":"Psychol Bull"},{"key":"10.3233\/JAD-220309_ref2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1037\/a0029597","article-title":"A conceptual framework for clinical 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