{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:09:25Z","timestamp":1787591365035,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:p>Background: Apathy is highly frequent in behavioral variant frontotemporal dementia (bvFTD). It is presumed to involve different pathophysiological mechanisms and neuroanatomical regions. Objective: We explored the hypothesis that subgroups showing distinct profiles of apathy and distinct patterns of atrophy within frontal lobes could be disentangled in bvFTD. Methods: Using data-driven clustering applied to 20 bvFTD patients, we isolated subgroups according to their profiles on the three subscales of the Dimensional Apathy Scale (DAS). We explored their apathy profiles and atrophy patterns. Apathy profiles were characterized through both subjective measures of apathy by questionnaires and measures including objective behavioral metrics. Atrophy patterns were obtained by voxel-based morphometry, contrasting each bvFTD subgroup with healthy controls (N\u200a=\u200a16). Results: By clustering based on DAS dimensions, we disentangled three subgroups of bvFTD patients, with distinct apathy profiles and atrophy patterns. One subgroup, which presented the smallest pattern of atrophy (including orbitofrontal cortex) with a right asymmetry, was characterized by high self-reported emotional and initiation apathy and by a self-initiation deficit reversible by external guidance. In other subgroups showing more diffuse bilateral atrophies extending to lateral prefrontal cortex, apathy was not reversible by external guidance and more difficulty to focus on goal-management was observed, especially in the subgroup with the largest atrophy and highest levels of executive apathy. Conclusion: Distinct clinical profiles of apathy, corresponding to distinct anatomical subtypes of bvFTD, were identified. These findings have implications for clinicians in a perspective of precision medicine as they could contribute to personalize treatments of apathy.<\/jats:p>","DOI":"10.3233\/jad-220370","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T14:19:11Z","timestamp":1663683551000},"page":"639-654","source":"Crossref","is-referenced-by-count":11,"title":["Disentangling Clinical Profiles of Apathy in Behavioral Variant Frontotemporal Dementia"],"prefix":"10.1177","volume":"90","author":[{"given":"Val\u00e9rie","family":"Godefroy","sequence":"first","affiliation":[{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute \u2013 ICM, Inserm, CNRS, AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Batrancourt","sequence":"additional","affiliation":[{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute \u2013 ICM, Inserm, CNRS, AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Charron","sequence":"additional","affiliation":[{"name":"INSERM U1266, Institut de Psychiatrie et Neurosciences de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"Department of Neuroradiology, H\u00f4pital Sainte-Anne, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabella","family":"Bouzigues","sequence":"additional","affiliation":[{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute \u2013 ICM, Inserm, CNRS, AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idil","family":"Sezer","sequence":"additional","affiliation":[{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute \u2013 ICM, Inserm, CNRS, AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bendetowicz","sequence":"additional","affiliation":[{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute \u2013 ICM, Inserm, CNRS, AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"},{"name":"Department of Neurology, IM2A, AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"},{"name":"Behavioural Neuropsychiatry Unit, AP-HP, H\u00f4pital de la Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilhem","family":"Carle","sequence":"additional","affiliation":[{"name":"Behavioural Neuropsychiatry Unit, AP-HP, H\u00f4pital de la Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Rametti-Lacroux","sequence":"additional","affiliation":[{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9, Institut du Cerveau - 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