{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:04:14Z","timestamp":1777395854558,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,9,27]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) and dementia with Lewy bodies (DLB) differ in their memory, attention, and visuoconstructional characteristics. The subscales of the well-known Mini-Mental State Examination (MMSE) provide an opportunity to assess these characteristics. Previous research has shown that analysis of the MMSE subscale performance of AD and DLB patients helps to differentiate them. Objective: Study the MMSE scores of AD and DLB patients to see if the ability of previously reported analyses to differentiate them could be improved. Include other dementia patients for perspective. Methods: We studied the MMSEs of all patients seen in our clinics during an 18-month period. Different equations were studied, derived from the subscales of Memory (M, 3 points maximum), Attention (A, 5 points maximum), and Pentagon-copying (P, 1 point maximum). Results: We obtained 400 MMSEs, 136 from AD patients and 24 from DLB patients, scoring range 1\u201330. The equation P minus M provided the best discrimination between AD and DLB. Using a P-M score\u200a=\u200a1 to identify AD, the positive predictive value was 0.97, negative predictive value 0.22, specificity 0.92, and sensitivity 0.43. As a secondary finding, the P-M\u200a=\u200a1 equation was also helpful to differentiate AD from Parkinson\u2019s disease dementia. Conclusion: Considering AD versus DLB in our clinic population, a demented patient who was unable to recall the three memory words on the MMSE but able to copy the intersecting pentagons had a 97% likelihood of having AD. Additional work is needed to improve the sensitivity of the P-M\u200a=\u200a1 equation.<\/jats:p>","DOI":"10.3233\/jad-220392","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T10:58:21Z","timestamp":1660301901000},"page":"1119-1129","source":"Crossref","is-referenced-by-count":7,"title":["A Mini-Mental State Examination Formula May Help to Distinguish Alzheimer\u2019s Disease from Dementia with Lewy Bodies"],"prefix":"10.1177","volume":"89","author":[{"given":"Tom","family":"Ala","sequence":"first","affiliation":[{"name":"Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Southern Illinois University School ofMedicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danah","family":"Bakir","sequence":"additional","affiliation":[{"name":"Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Southern Illinois University School ofMedicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srishti","family":"Goel","sequence":"additional","affiliation":[{"name":"Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Southern Illinois University School ofMedicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nida","family":"Feller","sequence":"additional","affiliation":[{"name":"Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Southern Illinois University School ofMedicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Botchway","sequence":"additional","affiliation":[{"name":"Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Southern Illinois University School ofMedicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Womack","sequence":"additional","affiliation":[{"name":"Dale and 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