{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:10:02Z","timestamp":1777396202805,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,22]]},"abstract":"<jats:p>Background: Reduced signal on fluorodeoxyglucose-positron emission tomography (FDG-PET) is a valid proxy for neurodegeneration in Alzheimer\u2019s disease (AD). Perivascular space (PVS) is believed to be associated with AD pathology and cognitive decline. Objective: This study aimed to investigate the associations of PVS with FDG-PET and cognitive performance based on the burden of amyloid pathology. Methods: We used magnetic resonance imaging (MRI) data from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI). MRI-visible PVS in basal ganglia (BG) and centrum semi-oval (CSO) were visually classified as: none\/mild, moderate or frequent\/severe. The association of PVS with brain FDG-PET was explored based on the burden of amyloid pathology, where a cerebrospinal fluid (CSF) t-tau\/A\u03b242 with the ratio\u22650.27 was defined as high amyloid pathology. Moreover, the relationships between PVS and cognitive performance variables (ADNI-MEM and ADNI-EF) were studied. Results: For participants with higher tau\/A\u03b242 ratio, CSO-PVS severity was independently associated with lower FDG-PET. There were significant interaction effects between moderate or frequent\/severe CSO-PVS and time on FDG decline in people with high amyloid pathology. The interaction between CSO-PVS and time (follow-up) was consistently associated with ADNI-MEM and ADNI-EF decline in individuals with high amyloid pathology. Conclusion: The study established the differential utility of PVS in BG and CSO for predicting brain metabolism. These findings suggest that CSO-PVS serves as a contributing factor to brain metabolism and cognitive decline associated with amyloid pathology.<\/jats:p>","DOI":"10.3233\/jad-220426","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T11:29:46Z","timestamp":1665746986000},"page":"1329-1337","source":"Crossref","is-referenced-by-count":4,"title":["Perivascular Space Predicts Brain Hypometabolism of Individuals with Underlying Amyloid Pathology"],"prefix":"10.1177","volume":"90","author":[{"given":"Xiaolei","family":"Shi","sequence":"first","affiliation":[{"name":"Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China"},{"name":"The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China"},{"name":"The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongshun","family":"Wu","sequence":"additional","affiliation":[{"name":"The Department of Radiology, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yachun","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China"},{"name":"Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Ning","sequence":"additional","affiliation":[{"name":"Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China"},{"name":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, 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