{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:10:15Z","timestamp":1777396215297,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,12,6]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) affects women more than men and consequently has been associated with menopause. Tibolone (TIB) has been used as a hormone replacement therapy to alleviate climacteric symptoms. Neuroprotective effects of TIB have also been reported in some animal models. Objective: This study aimed to assess the effect of TIB on memory and A\u03b2 peptides and tau protein content in the hippocampus and cerebellum of transgenic 3xTgAD ovariectomized mice. Methods: Three-month-old female mice were ovariectomized. Ten days after surgery, animals were divided into four groups: wild-type (WT)+vehicle; WT+TIB (1\u200amg\/kg); 3xTgAD+vehicle; and 3xTgAD+TIB (1\u200amg\/kg). TIB was administered for three months, and memory was evaluated using the object-in-context recognition task. Subsequently, animals were decapitated, and the hippocampus and cerebellum were dissected. Using commercial ELISA kits, these brain structures were homogenized in a PBS buffer for quantifying A\u03b240 and A\u03b242 and phosphorylated and total tau. Results A long-term memory deficit was observed in the 3xTgAD+vehicle group. In contrast, TIB treatment improved long-term memory in the 3xTgAD+TIB group than those treated with vehicle (p\u200a&lt;\u200a0.05). Furthermore, TIB treatment decreased A\u03b2 and tau content in the hippocampus of 3xTgAD mice compared to vehicle-treated groups (p\u200a&lt;\u200a0.05). No significant changes were observed in the cerebellum. Conclusion: Chronic treatment with TIB showed neuroprotective effects and delayed AD neuropathology in the 3xTgAD mice. Our results support hormone replacement therapy with TIB in menopausal women for neuroprotection.<\/jats:p>","DOI":"10.3233\/jad-220434","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T11:43:36Z","timestamp":1666093416000},"page":"1437-1447","source":"Crossref","is-referenced-by-count":5,"title":["Tibolone Improves Memory and Decreases the Content of Amyloid-\u03b2 Peptides and Tau Protein in the Hippocampus of a Murine Model of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"90","author":[{"given":"Julia J.","family":"Segura-Uribe","sequence":"first","affiliation":[{"name":"Subdirecci\u00f3n de Gesti\u00f3n de la Investigaci\u00f3n, Hospital Infantil de Mexico Federico G\u00f3mez, Secretarya de Salud, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Garc\u00eda-de la Torre","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzayaka","family":"Castillo-Mendieta","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Farmacologya, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Bribiesca-Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Farmacologya, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Orozco-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin A.","family":"Soriano-Urs\u00faa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Pinto-Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E.","family":"Fuentes-Venado","sequence":"additional","affiliation":[{"name":"Servicio de Medicina F\u00edsica y Rehabilitaci\u00f3n, Hospital General de Zona No 197, Texcoco, State of Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Guerra-Araiza","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Farmacologya, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220434_ref1","first-page":"223","article-title":"Alzheimer disease: autosomal dominant forms","volume":"165","author":"Guyant-Marechal","year":"2009","journal-title":"Rev Neurol (Paris)"},{"key":"10.3233\/JAD-220434_ref2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s004060050101","article-title":"Clinical features of Alzheimer\u2019s disease.","volume":"249","author":"F\u00f6rstl","year":"1999","journal-title":"Eur Arch Psychiatry Clin 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