{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:17:05Z","timestamp":1784276225242,"version":"3.55.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:p>We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset &lt;65 years) patients. They were stratified into A+N+, A\u2013 N+, and A\u2013 N\u2013 profiles via cerebrospinal fluid amyloid-\u03b21\u201342 (A), phosphorylated-tau (T), MRI medial temporal atrophy (neurodegeneration\u2013 N), and confluent white matter hyperintensities cerebrovascular disease (CVD). A, T, and CVD effects on longitudinal Mini-Mental State Examination (MMSE) were evaluated. A+N+ patients demonstrated steeper MMSE decline than A\u2013 N+ (\u03b2\u200a=\u200a1.53; p\u200a=\u200a0.036; CI 0.15:2.92) and A\u2013 N\u2013 (\u03b2\u200a=\u200a4.68; p\u200a=\u200a0.001; CI 1.98:7.38) over a mean follow-up of 1.24 years. Within A\u2013 N+, T\u2013 CVD+ patients showed greater MMSE decline compared to T+CVD\u2013 patients (\u03b2\u200a=\u200a\u2013 2.37; p\u200a=\u200a0.030; CI \u2013 4.41:\u2013 0.39). A+ results in significant cognitive decline, while CVD influences longitudinal cognition in the A\u2013 sub-group.<\/jats:p>","DOI":"10.3233\/jad-220448","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:31:33Z","timestamp":1663943493000},"page":"543-551","source":"Crossref","is-referenced-by-count":6,"title":["Amyloid-Tau-Neurodegeneration Profiles and Longitudinal Cognition in Sporadic Young-Onset Dementia"],"prefix":"10.1177","volume":"90","author":[{"given":"Ashwati","family":"Vipin","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore"},{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen Ling","family":"Koh","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Yi Xin","family":"Wong","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatin Zahra","family":"Zailan","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore"},{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne Yi","family":"Tan","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Ann","family":"Soo","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore"},{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaynii","family":"Satish","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Kumar","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore"},{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Zhiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline Su Lyn","family":"Ng","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore, Singapore"},{"name":"Duke-NUS Medical School, Singapore, 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