{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:09:31Z","timestamp":1777396171366,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,22]]},"abstract":"<jats:p>Background: Obstructive sleep apnea (OSA) is a multi-component disorder, which has many comorbidities, including cognitive impairment. Although its potential risk factors were unknown, they could affect the patient\u2019s quality of life and long-term prognosis. Objective: The purpose of this study was to investigate the application of urinary Alzheimer\u2019s disease-associated neurofilament protein (AD7c-NTP) levels in the assessment of cognitive impairment in OSA patients, and to analyze the predictive value of potential high-risk factors on cognitive impairment in OSA patients. Methods: 138 young and middle-aged adults were recruited and underwent overnight polysomnographic recording, Montreal Cognitive Assessment (MoCA), and urinary AD7c-NTP test. AD7c-NTP and other factors were further applied as biomarkers to develop a cognition risk prediction model. Results: Compared with the control, OSA patients showed significantly lower MoCA scores and higher urinary AD7c-NTP concentrations, while the severe OSA group appeared more significant. The urinary AD7c-NTP level of the OSA cognitive impairment group was higher than that of the non-cognitive impairment group. The results of regression analysis showed that urinary AD7c-NTP level was an independent predictor of cognitive impairment in OSA patients. Based on urinary AD7c-NTP levels and other selected factors, a multimodal prediction model for assessing the risk of cognitive impairment in OSA patients was initially established. Conclusion: The increased urinary AD7c-NTP level could be used as a relevant peripheral biomarker of cognitive impairment in OSA patients. A model using urinary AD7c-NTP combined with other factors was developed and could accurately assess the cognition risk of OSA patients.<\/jats:p>","DOI":"10.3233\/jad-220451","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T11:30:07Z","timestamp":1665747007000},"page":"1215-1231","source":"Crossref","is-referenced-by-count":3,"title":["The Association Between Cognition of Obstructive Sleep Apnea Patients and Urinary AD7c-NTP Level: Investigation and Application"],"prefix":"10.1177","volume":"90","author":[{"given":"Yumiao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meimei","family":"Kang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjie","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics, School of Basic Medicine, Shenzhen University Health Science, 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