{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:09:13Z","timestamp":1777396153028,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:p>Background: Accurate, cheap, and easy to promote methods for dementia prediction and early diagnosis are urgently needed in low- and middle-income countries. Integrating various cognitive tests using machine learning provides promising solutions. However, most effective machine learning models are black-box models that are hard to understand for doctors and could hide potential biases and risks. Objective: To apply cognitive-test-based machine learning models in practical dementia prediction and diagnosis by ensuring both interpretability and accuracy. Methods: We design a framework adopting Rule-based Representation Learner (RRL) to build interpretable diagnostic rules based on the cognitive tests selected by doctors. According to the visualization and test results, doctors can easily select the final rules after analysis and trade-off. Our framework is verified on the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) dataset (n\u200a=\u200a606) and Peking Union Medical College Hospital (PUMCH) dataset (n\u200a=\u200a375). Results: The predictive or diagnostic rules learned by RRL offer a better trade-off between accuracy and model interpretability than other representative machine learning models. For mild cognitive impairment (MCI) conversion prediction, the cognitive-test-based rules achieve an average area under the curve (AUC) of 0.904 on ADNI. For dementia diagnosis on subjects with a normal Mini-Mental State Exam (MMSE) score, the learned rules achieve an AUC of 0.863 on PUMCH. The visualization analyses also verify the good interpretability of the learned rules. Conclusion: With the help of doctors and RRL, we can obtain predictive and diagnostic rules for dementia with high accuracy and good interpretability even if only cognitive tests are used.<\/jats:p>","DOI":"10.3233\/jad-220502","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T14:19:49Z","timestamp":1663683589000},"page":"609-624","source":"Crossref","is-referenced-by-count":6,"title":["Learning Cognitive-Test-Based Interpretable Rules for Prediction and Early Diagnosis of Dementia Using Neural Networks"],"prefix":"10.1177","volume":"90","author":[{"given":"Zhuo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Computer Science and Technology, Tsinghua University, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1st, Dongcheng District, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Tsinghua University, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1st, Dongcheng District, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuxing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Tsinghua University, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1st, Dongcheng District, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Tsinghua University, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhui","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1st, Dongcheng District, Beijing, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Tsinghua University, Beijing, P.R. 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India","volume":"51","author":"Dias","year":"2009","journal-title":"Indian J Psychiatry"},{"key":"10.3233\/JAD-220502_ref7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000316119","article-title":"Nonpharmacologicaltherapies in Alzheimer\u2019s disease: A systematic review of efficacy","volume":"30","author":"Olazar\u00e1n","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-220502_ref9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal CognitiveAssessment, MoCA: A brief screening tool for mild cognitiveimpairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-220502_ref10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1001\/jamainternmed.2015.2152","article-title":"Cognitive tests to detect dementia: A systematic review and meta-analysis","volume":"175","author":"Tsoi","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.3233\/JAD-220502_ref11","first-page":"e12135","article-title":"Analyzing large Alzheimer\u2019s disease cognitive datasets: Considerations and challenges","volume":"12","author":"Bellio","year":"2020","journal-title":"Alzheimers Dementia (Amst)"},{"key":"10.3233\/JAD-220502_ref12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1532-5415.1992.tb01992.x","article-title":"The mini-mental state examination: A comprehensive review","volume":"40","author":"Tombaugh","year":"1992","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-220502_ref13","doi-asserted-by":"crossref","first-page":"e1002250","DOI":"10.1371\/journal.pmed.1002250","article-title":"Early diagnosis of mild cognitive impairment basic and mild dementia through and instrumental activities of daily living: Development of a new evaluation 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Gerontol"},{"key":"10.3233\/JAD-220502_ref17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-220502_ref18","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.12688\/f1000research.11603.1","article-title":"The emerging role of PET imaging in dementia","volume":"6","author":"Iaccarino","year":"2017","journal-title":"F1000Res"},{"key":"10.3233\/JAD-220502_ref19","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1001\/archneur.61.12.1930","article-title":"APOE genotype, family history of dementia, and Alzheimer disease risk: A 6-year follow-up study","volume":"61","author":"Huang","year":"2004","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-220502_ref20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41591-018-0316-z","article-title":"A guide to 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Adv Neural Inf Process Syst 32."},{"key":"10.3233\/JAD-220502_ref39","unstructured":"Kleinbaum DG , Dietz K , Gail M , Klein M , Klein M (2002) Logistic Regression, Springer. ."},{"key":"10.3233\/JAD-220502_ref40","doi-asserted-by":"crossref","unstructured":"Sch\u00f6lkopf B , Smola AJ , Bach F (2002) Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond, MIT press.","DOI":"10.7551\/mitpress\/4175.001.0001"},{"key":"10.3233\/JAD-220502_ref41","first-page":"1244","article-title":"Exact and consistent interpretation for piecewise linear neural networks: A closed form solution","volume":"24","author":"Chu","year":"2018","journal-title":"International Conference on Knowledge Discovery & Data Mining"},{"key":"10.3233\/JAD-220502_ref42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach 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