{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:07:15Z","timestamp":1777396035803,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:p>Background: Amyloid-\u03b2 protein precursor (A\u03b2PP) is enriched in neurons. However, the mechanism underlying A\u03b2PP regulation of neuronal activity is poorly understood. Potassium channels are critically involved in neuronal excitability. In hippocampus, A-type potassium channels are highly expressed and involved in determining neuronal spiking. Objective: We explored hippocampal local field potential (LFP) and spiking in the presence and absence of A\u03b2PP, and the potential involvement of an A-type potassium channel. Methods: We used in vivo extracellular recording and whole-cell patch-clamp recording to determine neuronal activity, current density of A-type potassium currents, and western blot to detect changes in related protein levels. Results: Abnormal LFP was observed in A\u03b2PP\u2013\/\u2013 mice, including reduced beta and gamma power, and increased epsilon and ripple power. The firing rate of glutamatergic neurons reduced significantly, in line with an increased action potential rheobase. Given that A-type potassium channels regulate neuronal firing, we measured the protein levels and function of two major A-type potassium channels and found that the post-transcriptional level of Kv1.4, but not Kv4.2, was significantly increased in the A\u03b2PP\u2013\/\u2013 mice. This resulted in a marked increase in the peak time of A-type transient outward potassium currents in both glutamatergic and gamma-aminobutyric acid-ergic (GABAergic) neurons. Furthermore, a mechanistic experiment using human embryonic kidney 293 (HEK293) cells revealed that the A\u03b2PP deficiency-induced increase in Kv1.4 may not involve protein-protein interaction between A\u03b2PP and Kv1.4. Conclusion: This study suggests that A\u03b2PP modulates neuronal firing and oscillatory activity in the hippocampus, and Kv1.4 may be involved in mediating the modulation.<\/jats:p>","DOI":"10.3233\/jad-220606","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T11:26:27Z","timestamp":1677583587000},"page":"1241-1256","source":"Crossref","is-referenced-by-count":2,"title":["Amyloid-\u03b2 Protein Precursor Regulates Electrophysiological Properties in the Hippocampus via Altered Kv1.4 Expression and Function in Mice"],"prefix":"10.1177","volume":"92","author":[{"given":"Yi","family":"Li","sequence":"first","affiliation":[{"name":"South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research, Panyu Central Hospital, Guangzhou, China"},{"name":"School of Life Sciences, South China Normal University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, South China Normal University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-ming","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, South China Normal University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, South China Normal University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Guangzhou University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Long","sequence":"additional","affiliation":[{"name":"South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research, Panyu Central Hospital, Guangzhou, China"},{"name":"School of Life Sciences, South China Normal University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220606_ref1","doi-asserted-by":"crossref","first-page":"101801","DOI":"10.1016\/j.pneurobio.2020.101801","article-title":"Presynaptic failure in Alzheimer\u2019s disease","volume":"194","author":"Barthet","year":"2020","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-220606_ref2","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1093\/hmg\/ddp323","article-title":"Potential late-onset Alzheimer\u2019s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity","volume":"18","author":"Kim","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-220606_ref3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.279.5348.242","article-title":"Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer\u2019s and Down patients","volume":"279","author":"van Leeuwen","year":"1998","journal-title":"Science"},{"key":"10.3233\/JAD-220606_ref4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/jnr.23823","article-title":"Restoring soluble amyloid precursor protein alpha functions as a potential treatment for Alzheimer\u2019s disease","volume":"95","author":"Habib","year":"2017","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-220606_ref5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00221-011-2894-6","article-title":"The role of APP and APLP for synaptic transmission, plasticity, and network function: Lessons from genetic mouse models","volume":"217","author":"Korte","year":"2012","journal-title":"Exp Brain Res"},{"key":"10.3233\/JAD-220606_ref6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1126\/science.aaw0636","article-title":"Neuronal function of Alzheimer\u2019s protein","volume":"363","author":"Korte","year":"2019","journal-title":"Science"},{"key":"10.3233\/JAD-220606_ref7","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.biopsych.2007.02.027","article-title":"Cortical plasticity in Alzheimer\u2019s disease in humans and rodents","volume":"62","author":"Battaglia","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.3233\/JAD-220606_ref8","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1523\/JNEUROSCI.2774-16.2016","article-title":"Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses","volume":"37","author":"Prieto","year":"2017","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mcn.2012.07.009","article-title":"Amyloid precursor protein (APP) regulates synaptic structure and function","volume":"51","author":"Tyan","year":"2012","journal-title":"Mol Cell Neurosci"},{"key":"10.3233\/JAD-220606_ref10","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1523\/JNEUROSCI.1026-07.2007","article-title":"The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice","volume":"27","author":"Ring","year":"2007","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref11","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1523\/JNEUROSCI.1826-18.2019","article-title":"Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha","volume":"39","author":"Mockett","year":"2019","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref12","doi-asserted-by":"crossref","first-page":"660208","DOI":"10.3389\/fnmol.2021.660208","article-title":"Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca(2+)-permeable AMPA receptors","volume":"14","author":"Livingstone","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"10.3233\/JAD-220606_ref13","doi-asserted-by":"crossref","first-page":"e20142","DOI":"10.7554\/eLife.20142","article-title":"APP modulates KCC2 expression and function in hippocampal GABAergic inhibition","volume":"6","author":"Chen","year":"2017","journal-title":"Elife"},{"key":"10.3233\/JAD-220606_ref14","doi-asserted-by":"crossref","first-page":"15660","DOI":"10.1523\/JNEUROSCI.4104-09.2009","article-title":"Amyloid precursor protein regulates Ca(v)1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity","volume":"29","author":"Yang","year":"2009","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1471-4159.2009.06560.x","article-title":"MicroRNA-92 modulates K(+) Cl(-) co-transporter KCC2 expression in cerebellar granule neurons","volume":"113","author":"Barbato","year":"2010","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-220606_ref16","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1523\/JNEUROSCI.22-23-10106.2002","article-title":"Potassium currents during the action potential of hippocampal CA3 neurons","volume":"22","author":"Mitterdorfer","year":"2002","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jchemneu.2003.07.006","article-title":"Immunohistochemical localization of the voltage-gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat","volume":"26","author":"Lujan","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"10.3233\/JAD-220606_ref19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1523\/JNEUROSCI.18-03-00965.1998","article-title":"Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus","volume":"18","author":"Cooper","year":"1998","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref20","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1523\/JNEUROSCI.0174-12.2012","article-title":"I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity","volume":"32","author":"Granados-Fuentes","year":"2012","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref21","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1523\/JNEUROSCI.23-12-05079.2003","article-title":"Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits","volume":"23","author":"Hopf","year":"2003","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref22","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1113\/jphysiol.2012.229013","article-title":"A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons","volume":"590","author":"Carrasquillo","year":"2012","journal-title":"J Physiol"},{"key":"10.3233\/JAD-220606_ref23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0092-8674(95)90073-X","article-title":"beta-Amyloid precursorprotein-deficient mice show reactive gliosis and decreased locomotoractivity","volume":"81","author":"Zheng","year":"1995","journal-title":"Cell"},{"key":"10.3233\/JAD-220606_ref24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/cne.10905","article-title":"Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse","volume":"467","author":"Tamamaki","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.3233\/JAD-220606_ref25","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuropharm.2016.06.021","article-title":"Altered striatal rhythmic activity in cylindromatosis knock-out mice due to enhanced GABAergic inhibition","volume":"110","author":"Zhang","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.3233\/JAD-220606_ref26","doi-asserted-by":"crossref","first-page":"113805","DOI":"10.1016\/j.expneurol.2021.113805","article-title":"Altered corticostriatal synchronization associated with compulsive-like behavior in APP\/PS1 mice","volume":"344","author":"Peng","year":"2021","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-220606_ref27","doi-asserted-by":"crossref","first-page":"e20142","DOI":"10.1186\/s13024-021-00434-7","article-title":"Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models","volume":"16","author":"Chen","year":"2021","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-220606_ref29","doi-asserted-by":"crossref","first-page":"13485","DOI":"10.1523\/JNEUROSCI.2882-06.2006","article-title":"Phase precession in hippocampal interneurons showing strong functional coupling to individual pyramidal cells","volume":"26","author":"Maurer","year":"2006","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref30","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hipo.20202","article-title":"Organization of hippocampal cell assemblies based on theta phaseprecession","volume":"16","author":"Maurer","year":"2006","journal-title":"Hippocampus"},{"key":"10.3233\/JAD-220606_ref31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0896-6273(00)80525-5","article-title":"Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: An ensemble approach in the behaving rat","volume":"21","author":"Csicsvari","year":"1998","journal-title":"Neuron"},{"key":"10.3233\/JAD-220606_ref32","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v031.i10"},{"key":"10.3233\/JAD-220606_ref33","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1523\/JNEUROSCI.20-11-04145.2000","article-title":"A-type K+ current mediated by the Kv4 channel regulates the generation of action potential in developing cerebellar granule cells","volume":"20","author":"Shibata","year":"2000","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF00374949","article-title":"Patch-clamp recordings from the soma and dendrites of neurons in brain-slices using infrared video microscopy","volume":"423","author":"Stuart","year":"1993","journal-title":"Pflugers Arch"},{"key":"10.3233\/JAD-220606_ref35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/1073858413504003","article-title":"IA channels: Diverse regulatory mechanisms","volume":"20","author":"Carrasquillo","year":"2014","journal-title":"Neuroscientist"},{"key":"10.3233\/JAD-220606_ref36","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1523\/JNEUROSCI.2858-05.2005","article-title":"Functional role of the fast transient outward K+ current IA in pyramidal neurons in (rat) primary visual cortex","volume":"25","author":"Yuan","year":"2005","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0896-6273(92)90166-B","article-title":"Subcellular segregation of two A-type K+ channel proteins in rat central neurons","volume":"9","author":"Sheng","year":"1992","journal-title":"Neuron"},{"key":"10.3233\/JAD-220606_ref38","doi-asserted-by":"crossref","first-page":"e61198","DOI":"10.1371\/journal.pone.0061198","article-title":"Hippocampal network oscillations in APP\/APLP2-deficient mice","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-220606_ref39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.celrep.2019.08.103","article-title":"The amyloid precursor protein C-terminal domain alters CA1neuron firing, modifying hippocampus oscillations and impairingspatial memory encoding","volume":"29","author":"Pousinha","year":"2019","journal-title":"Cell Rep"},{"key":"10.3233\/JAD-220606_ref40","doi-asserted-by":"crossref","first-page":"21948","DOI":"10.1038\/srep21948","article-title":"Impaired theta-gamma coupling in APP-deficient mice","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-220606_ref41","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1523\/JNEUROSCI.4130-15.2016","article-title":"Amyloid precursor protein protects neuronal network function after hypoxia via control of voltage-gated calcium channels","volume":"36","author":"Hefter","year":"2016","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3233\/JAD-180503","article-title":"Impaired spike timing dependent cortico-cortical plasticity in Alzheimer\u2019s disease patients","volume":"66","author":"Di Lorenzo","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-220606_ref43","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.3390\/cells11152375","article-title":"microRNA-mediated silencing pathways in the nervous system and neurological diseases","volume":"11","author":"Barbato","year":"2022","journal-title":"Cells"},{"key":"10.3233\/JAD-220606_ref44","doi-asserted-by":"crossref","first-page":"16079","DOI":"10.1038\/ncomms16079","article-title":"microRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain","volume":"8","author":"Sakai","year":"2017","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-220606_ref45","doi-asserted-by":"crossref","first-page":"705581","DOI":"10.3389\/fimmu.2021.705581","article-title":"Elevated expression of miR-17 in microglia of Alzheimer\u2019s disease patients abrogates autophagy-mediated amyloid-beta degradation","volume":"12","author":"Estfanous","year":"2021","journal-title":"Front Immunol"},{"key":"10.3233\/JAD-220606_ref46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-1326-3-10","article-title":"microRNAs can regulate human APP levels","volume":"3","author":"Patel","year":"2008","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-220606_ref47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2008.11.009","article-title":"microRNA regulation of Alzheimer\u2019s amyloid precursor protein expression","volume":"33","author":"Hebert","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-220606_ref48","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1074\/jbc.M110.112664","article-title":"microRNA-101 regulates amyloid precursor protein expression in hippocampal neurons","volume":"285","author":"Vilardo","year":"2010","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-220606_ref49","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neurobiolaging.2010.04.034","article-title":"microRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer\u2019s-associated pathogenesis in SAMP8 mice","volume":"33","author":"Liu","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-220606_ref50","doi-asserted-by":"crossref","first-page":"31298","DOI":"10.1074\/jbc.M112.366336","article-title":"microRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients","volume":"287","author":"Long","year":"2012","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-220606_ref51","doi-asserted-by":"crossref","first-page":"11597","DOI":"10.1074\/jbc.275.16.11597","article-title":"Surface expression of Kv1 channels is governed by a C-terminal motif","volume":"275","author":"Li","year":"2000","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-220606_ref52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00232-014-9756-7","article-title":"The degree of N-glycosylation affects the trafficking and cell surface expression levels of Kv1.4 potassium channels","volume":"248","author":"Watanabe","year":"2015","journal-title":"J Membr Biol"},{"key":"10.3233\/JAD-220606_ref53","doi-asserted-by":"crossref","first-page":"39419","DOI":"10.1074\/jbc.M107399200","article-title":"Determinants involved in Kv1 potassium channel folding in the endoplasmic reticulum, glycosylation in the Golgi, and cell surface expression","volume":"276","author":"Zhu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-220606_ref54","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCRESAHA.114.303167","article-title":"Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries","volume":"114","author":"Moore","year":"2014","journal-title":"Circ Res"},{"key":"10.3233\/JAD-220606_ref55","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3233\/JAD-201557","article-title":"Amyloid-beta protein precursor deficiency changes neuronal electrical activity and levels of mitochondrial proteins in the medial prefrontal cortex","volume":"81","author":"Huo","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-220606_ref56","first-page":"4060","article-title":"Prefrontal cortical GABAergic dysfunction contributes to aberrant UP-state duration in APP knockout mice","volume":"27","author":"Huo","year":"2017","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-220606_ref57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3940(90)90236-3","article-title":"GABAB agonists modulate a transient potassium current in cultured mammalian hippocampal neurons","volume":"118","author":"Saint","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-220606_ref58","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neuroscience.2003.09.022","article-title":"Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons","volume":"123","author":"Takeda","year":"2004","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-220606_ref59","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fncel.2019.00222","article-title":"Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons","volume":"13","author":"Bonetto","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.3233\/JAD-220606_ref60","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.neuroscience.2005.04.065","article-title":"Postsynaptic and extrasynaptic localization of Kv4.2 channels in the mouse hippocampal region, with special reference to targeted clustering at gabaergic synapses","volume":"134","author":"Jinno","year":"2005","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-220606_ref61","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1523\/JNEUROSCI.3208-06.2007","article-title":"Kv4.3-mediated A-type K+ currents underlie rhythmic activity in hippocampal interneurons","volume":"27","author":"Bourdeau","year":"2007","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref62","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1523\/JNEUROSCI.2599-06.2006","article-title":"Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses","volume":"26","author":"Burkhalter","year":"2006","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-220606_ref63","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fnagi.2014.00254","article-title":"Homotaurine induces measurable changes of short latency afferent inhibition in a group of mild cognitive impairment individuals","volume":"6","author":"Martorana","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-220606_ref64","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.brs.2020.05.013","article-title":"LTP-like cortical plasticity predicts conversion to dementia in patients with memory impairment","volume":"13","author":"Di Lorenzo","year":"2020","journal-title":"Brain Stimul"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-220606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:24Z","timestamp":1777370844000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-220606"}},"subtitle":[],"editor":[{"given":"Ling-Qiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":62,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-220606","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]}}}