{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:08:59Z","timestamp":1777396139366,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,5,30]]},"abstract":"<jats:p>Background: Patients with Alzheimer\u2019s disease (AD) have an increased risk of developing epileptiform discharges, which is associated with a more rapid rate of progression. This suggests that suppression of epileptiform activity could have clinical benefit in patients with AD. Objective: In the current study, we tested whether acute, intravenous administration of levetiracetam led to changes in brain perfusion as measured with arterial spin labeling MRI (ASL-MRI) in AD. Methods: We conducted a double-blind, within-subject crossover design study in which participants with mild AD (n\u200a=\u200a9) received placebo, 2.5\u200amg\/kg, and 7.5\u200amg\/kg of LEV intravenously in a random order in three sessions. Afterwards, the participants underwent ASL-MRI. Results: Analysis of relative cerebral blood flow (rCBF) between 2.5\u200amg of levetiracetam and placebo showed significant decreases in a cluster that included the posterior cingulate cortex, the precuneus, and the posterior part of the cingulate gyrus, while increased cerebral blood flow was found in both temporal lobes involving the hippocampus. Conclusion: Administration of 2.5\u200amg\/kg of LEV in patients without any history of epilepsy leads to changes in rCBF in areas known to be affected in the early stages of AD. These areas may be the focus of the epileptiform activity. Larger studies are needed to confirm the current findings.<\/jats:p>","DOI":"10.3233\/jad-220614","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:28:47Z","timestamp":1682684927000},"page":"939-948","source":"Crossref","is-referenced-by-count":11,"title":["Levetiracetam Increases Hippocampal Blood Flow in Alzheimer\u2019s Disease as Measured by Arterial Spin Labelling MRI"],"prefix":"10.1177","volume":"93","author":[{"given":"Daniel Zvi","family":"Press","sequence":"first","affiliation":[{"name":"Berenson-Allen Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Sand\u00f8e","family":"Musaeus","sequence":"additional","affiliation":[{"name":"Berenson-Allen Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"},{"name":"Department of 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