{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:01:24Z","timestamp":1791907284213,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease cerebrospinal fluid (CSF) biomarkers amyloid-\u03b2 1\u201342 (A\u03b242), total tau (T-tau), and phosphorylated tau 181 (P-tau181) are widely used. However, concentration gradient of these biomarkers between intraventricular (V-CSF) and lumbar CSF (L-CSF) has been demonstrated in idiopathic normal pressure hydrocephalus (iNPH), potentially affecting clinical utility. Objective: Here we aim to provide conversion factors for clinical and research use between V-CSF and L-CSF. Methods: Altogether 138 iNPH patients participated. L-CSF samples were obtained prior to shunt surgery. Intraoperative V-CSF samples were obtained from 97 patients. Post-operative follow-up L- and V-CSF (shunt reservoir) samples of 41 patients were obtained 1\u201373 months after surgery and then after 3, 6, and 18 months. CSF concentrations of A\u03b242, T-tau, and P-tau181 were analyzed using commercial ELISA assays. Results: Preoperative L-CSF A\u03b242, T-tau, and P-tau181 correlated to intraoperative V-CSF (\u03c1=\u200a0.34\u20130.55, p\u200a&lt;\u200a0.001). Strong correlations were seen between postoperative L- and V-CSF for all biomarkers in every follow-up sampling point (\u03c1s A\u03b242: 0.77\u20130.88, T-tau: 0.91\u20130.94, P-tau181: 0.94\u20130.96, p\u200a&lt;\u200a0.0001). Regression equations were determined for intraoperative V- and preoperative L-CSF (A\u03b242: V-CSF\u200a=\u200a185+0.34*L-CSF, T-tau: Ln(V-CSF)\u200a=\u200a3.11+0.49*Ln(L-CSF), P-tau181: V-CSF\u200a=\u200a8.2+0.51*L-CSF), and for postoperative V- and L-CSF (A\u03b242: V-CSF\u200a=\u200a86.7+0.75*L-CSF, T-tau: V-CSF\u200a=\u200a86.9+0.62*L-CSF, P-tau181: V-CSF\u200a=\u200a2.6+0.74*L-CSF). Conclusion: A\u03b242, T-tau, and P-tau181 correlate linearly in-between V- and L-CSF, even stronger after CSF shunt surgery. Equations presented here, provide a novel tool to use V-CSF for diagnostic and prognostic entities relying on the L-CSF concentrations and can be applicable to clinical use when L-CSF samples are not available or less invasively obtained shunt reservoir samples should be interpreted.<\/jats:p>","DOI":"10.3233\/jad-220652","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:41:39Z","timestamp":1668512499000},"page":"305-319","source":"Crossref","is-referenced-by-count":4,"title":["Concordance of Alzheimer\u2019s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1177","volume":"91","author":[{"given":"Heikki","family":"Lukkarinen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurosurgery, University of Eastern Finland and Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksi","family":"Vanninen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurosurgery, University of Eastern Finland and Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Tesseur","sequence":"additional","affiliation":[{"name":"UCB Biopharma SRL, Braine-l\u2019Alleud, Belgium"},{"name":"Janssen Research & Development, A division of Janssen Pharmaceutica NV, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrel","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Janssen Research & Development, A division of Janssen Pharmaceutica NV, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Van Der Ark","sequence":"additional","affiliation":[{"name":"Janssen Research & Development, A division of Janssen Pharmaceutica NV, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Kokkola","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK"},{"name":"UK Dementia Research Institute, UCL, London, UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Leinonen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurosurgery, University of Eastern Finland and Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220652_ref1","doi-asserted-by":"crossref","first-page":"S2\u20134","DOI":"10.1227\/01.NEU.0000168185.29659.C5","article-title":"Diagnosing idiopathic normal-pressure hydrocephalus","volume":"57","author":"Relkin","year":"2005","journal-title":"Neurosurgery"},{"key":"10.3233\/JAD-220652_ref2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2176\/nmc.52.775","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus: Second edition","volume":"52","author":"Mori","year":"2012","journal-title":"Neurol Med Chir 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