{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:32:09Z","timestamp":1791333129274,"version":"4.3.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:p>Background: The long-term effects of traumatic brain injury (TBI) with loss of consciousness (LOC) on magnetic resonance imaging (MRI) markers of brain health and on dementia risk are still debated. Objective: To investigate the associations of history of TBI with LOC with incident dementia and neuroimaging markers of brain structure and small vessel disease lesions. Methods: The analytical sample consisted in 4,144 participants aged 65 and older who were dementia-free at baseline from the Three City \u2013Dijon study. History of TBI with LOC was self-reported at baseline. Clinical Dementia was assessed every two to three years, up to 12 years of follow-up. A subsample of 1,675 participants &lt;80 years old underwent a brain MRI at baseline. We investigated the associations between history of TBI with LOC and 1) incident all cause and Alzheimer\u2019s disease (AD) dementia using illness-death models, and 2) neuroimaging markers at baseline. Results: At baseline, 8.3% of the participants reported a history of TBI with LOC. In fully-adjusted models, participants with a history of TBI with LOC had no statistically significant differences in dementia risk (HR\u200a=\u200a0.90, 95% CI\u200a=\u200a0.60\u20131.36) or AD risk (HR\u200a=\u200a1.03, 95% CI\u200a=\u200a0.69\u20131.52), compared to participants without TBI history. History of TBI with LOC was associated with lower white matter volume (\u03b2=\u200a\u20134.58, p\u200a=\u200a0.048), but not with other brain volumes, white matter hyperintensities volume, nor covert brain infarct. Conclusion: This study did not find evidence of an association between history of TBI with LOC and dementia or AD dementia risks over 12-year follow-up, brain atrophy, or markers of small vessel disease.<\/jats:p>","DOI":"10.3233\/jad-220658","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T12:48:55Z","timestamp":1674564535000},"page":"183-193","source":"Crossref","is-referenced-by-count":7,"title":["How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort"],"prefix":"10.1177","volume":"92","author":[{"given":"Leslie","family":"Grasset","sequence":"first","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; CIC1401-EC, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda C.","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Crivello","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tzourio","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Ch\u00eane","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; CIC1401-EC, Bordeaux, France"},{"name":"Pole de sante publique Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Dufouil","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; CIC1401-EC, Bordeaux, France"},{"name":"Pole de sante publique Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220658_ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Dementia Collaborators","year":"2019","journal-title":"Lancet 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