{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:11:28Z","timestamp":1787062288799,"version":"build-2736575974"},"reference-count":72,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:p>Background: Pathological and clinical features of Alzheimer\u2019s disease (AD) are in temporal discrepancy and currently accepted clinical tests provide the diagnosis decades after the initial pathophysiological events. In order to enable a more timely detection of AD, research efforts are directed to identification of biomarkers of the early symptomatic stage. Neuroinflammatory signaling pathways and inflammation-related microRNAs (miRNAs) could possibly have a crucial role in AD, making them promising potential biomarkers. Objective: We examined the expression of circulatory miRNAs with a documented role in AD pathophysiology: miR-29a\/b, miR-101, miR-125b, miR-146a, and miR-155 in the plasma of AD patients (AD, n\u200a=\u200a12), people with mild cognitive impairment (MCI, n\u200a=\u200a9), and normocognitive group (CTRL, n\u200a=\u200a18). We hypothesized that these miRNA expression levels could correlate with the level of participants\u2019 cognitive decline. Methods: The study participants completed the standardized interview, neurological examination, neuropsychological assessment, and biochemical analyses. miRNA expression levels were assessed by RT-PCR. Results: Neurological and laboratory findings could not account for MCI, but miR-146a and -155 were upregulated in the MCI group compared to the control. miR-146a, known to mediate early neuroinflammatory AD events, was also upregulated in the MCI compared to AD group. ROC curve analysis for miRNA-146a showed 77.8% sensitivity and 94.4% specificity and 66.7% sensitivity and 88.9% specificity for miR-155. Conclusion: Determination of circulatory inflamma-miRs-146a and -155 expression, together with neuropsychological screening, could become a non-invasive tool for detecting individuals with an increased risk for AD, but research on a larger cohort is warranted.<\/jats:p>","DOI":"10.3233\/jad-220676","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T14:21:36Z","timestamp":1663683696000},"page":"625-638","source":"Crossref","is-referenced-by-count":11,"title":["Inflammation-Related microRNAs-146a and -155 Are Upregulated in Mild Cognitive Impairment Subjects Among Older Age Population in Montenegro"],"prefix":"10.1177","volume":"90","author":[{"given":"Isidora","family":"Rov\u010danin Dragovi\u0107","sequence":"first","affiliation":[{"name":"University of Montenegro, Faculty of Medicine, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nata\u0161a","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"University of Montenegro, Faculty of Medicine, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0161a","family":"\u017ddralevi\u0107","sequence":"additional","affiliation":[{"name":"University of Montenegro, Faculty of Medicine, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Radulovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center of Montenegro, Department of Neurology, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijana","family":"Vukovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center of Montenegro, Department of Neurology, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaviana","family":"Marzano","sequence":"additional","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, CNR, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apollonia","family":"Tullo","sequence":"additional","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, CNR, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Radunovi\u0107","sequence":"additional","affiliation":[{"name":"University of Montenegro, Faculty of Medicine, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220676_ref1","doi-asserted-by":"crossref","unstructured":"(2022) 2022 Alzheimer\u2019s disease facts and figures. 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