{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:32:00Z","timestamp":1790688720007,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:p>Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50\u201390 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score \u226522, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.\u20131.0. The Quality of Life in Alzheimer \u2019s Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman\u2019s rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment.<\/jats:p>","DOI":"10.3233\/jad-220696","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:31:55Z","timestamp":1663943515000},"page":"719-726","source":"Crossref","is-referenced-by-count":18,"title":["Quality of Life and the Experience of Living with Early-Stage Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"90","author":[{"given":"Alberto","family":"Villarejo-Galende","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (I+12), Madrid, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garc\u00eda-Arcelay","sequence":"additional","affiliation":[{"name":"Medical Department, Roche Farma, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pi\u00f1ol-Ripoll","sequence":"additional","affiliation":[{"name":"Cognitive Disorders Unit, Hospital Universitari Santa Maria de Lleida, Institut de Recerca Biom\u00e9dica de Lleida (IRBLLeida), Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"del Olmo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Dr. Peset, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Vi\u00f1uela","sequence":"additional","affiliation":[{"name":"Instituto Neurol\u00f3gico Andaluz, Hospital Victoria Eugenia, Unidad Deterioro Cognitivo, Hospital Universitario Virgen Macarena, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Boada","sequence":"additional","affiliation":[{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Franco-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Dementia Unit, Department of Neurology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Iba\u00f1ez de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n de Parkinson, Policl\u00ednica Guip\u00fazcoa, San Sebasti\u00e1n, 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Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Baquero-Toledo","sequence":"additional","affiliation":[{"name":"Grup d\u2019Investigaci\u00f3 en Malaltia d\u2019Alzheimer, Department of Neurology, Hospital Universitari i Polit\u00e8cnic La Fe, Institut d\u2019Investigaci\u00f3 Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Feria-Vilar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and other Cognitive Disorders Unit, Hospital Cl\u00ednic, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Berbel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Central de la Cruz Roja, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL), Universidad de Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Vieira-Campos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de La Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garc\u00eda-Ribas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario 12 de 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