{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:05:13Z","timestamp":1777395913610,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>Background: The apolipoprotein E (APOE) \u025b4 allele confers risk for age and Alzheimer\u2019s disease related cognitive decline but the mechanistic link remains poorly understood. Blood oxygenation level dependent (BOLD) response in the fusiform gyrus (FG) during object naming appears greater among APOE \u025b4 carriers even in the face of equivalent cognitive performance, suggesting neural compensation. However, BOLD is susceptible to known age and APOE-related vascular changes that could confound its interpretation. Objective: To address this limitation, we used calibrated fMRI during an object naming task and a hypercapnic challenge to obtain a more direct measure of neural function \u2013 percent change cerebral metabolic rate of oxygen consumption (%\u0394CMRO2). Methods: Participants were 45 older adults without dementia (28 \u025b4\u2013, 17 \u025b4+) between the ages of 65 and 85. We examined APOE-related differences in %\u0394CMRO2 in the FG during object naming and the extent to which APOE modified associations between FG %\u0394CMRO2 and object naming accuracy. Exploratory analyses also tested the hypothesis that %\u0394CMRO2 is less susceptible to vascular compromise than are measures of %\u0394CBF and %\u0394BOLD. Results: We observed a modifying role of APOE on associations between FG %\u0394CMRO2 and cognition, with \u025b4 carriers (but not non-carriers) demonstrating a positive association between right FG %\u0394CMRO2 and object naming accuracy. Conclusion: Results suggest that the relationship between neural function and cognition is altered among older adult APOE \u025b4 carriers prior to the onset of dementia, implicating CMRO2 response as a potential mechanism to support cognition in APOE-related AD risk.<\/jats:p>","DOI":"10.3233\/jad-220749","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T12:23:00Z","timestamp":1673353380000},"page":"1371-1383","source":"Crossref","is-referenced-by-count":2,"title":["APOE Genotype Modifies the Association of Fusiform Gyrus Cerebral Metabolic Rate of Oxygen Consumption and Object Naming Performance"],"prefix":"10.1177","volume":"91","author":[{"given":"Chelsea C.","family":"Hays Weeks","sequence":"first","affiliation":[{"name":"VA San Diego Healthcare System, San Diego, CA, USA"},{"name":"Department of Psychiatry, UC San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvinka 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