{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:05:19Z","timestamp":1777395919817,"version":"3.51.4"},"reference-count":68,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>Background: The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC. Objective: We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database. Methods: FIT-positive participants were collected from a database provided by the Korean National Health Insurance Service. Results: The incidence of all kinds of dementia was higher in FIT-positive than FIT-negative subjects (p\u200a&lt;\u200a0.0001). FIT-positive participants had a higher risk of Alzheimer\u2019s disease (AD) (p\u200a&lt;\u200a0.0001) and vascular dementia (p\u200a=\u200a0.0002), compared to participants with FIT negativity. The risk of all kinds of dementia or AD in FIT-positive participants was higher in younger (age\u200a&lt;\u200a65 years) than older participants (p\u200a&lt;\u200a0.0001 for all kinds of dementia; p\u200a=\u200a0.0002 for AD). Conclusion: FIT positivity was correlated with an increased risk of dementia, especially in participants under 65 years of age. The study suggests that clinicians can consider dementia when FIT-positive participants fail to show any malignancies.<\/jats:p>","DOI":"10.3233\/jad-220770","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T12:24:58Z","timestamp":1673612698000},"page":"1515-1525","source":"Crossref","is-referenced-by-count":1,"title":["Positive Results from the Fecal Immunochemical Test Can Be Related to Dementia: A Nationwide Population-Based Study in South Korea"],"prefix":"10.1177","volume":"91","author":[{"given":"Yu Kyung","family":"Jun","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedicine & Health Sciences, College of Medicine, Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Min","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-ang University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Joon","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220770_ref1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4143\/crt.2016.186","article-title":"Trends in participation rates for the National Cancer Screening Program in Korea, 2002-2012","volume":"49","author":"Suh","year":"2017","journal-title":"Cancer Res 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