{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:44:01Z","timestamp":1793598241315,"version":"4.5.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>Background: Loneliness has been highlighted as a risk factor for dementia. However, the nature of the relationship between loneliness and cognitive function prior to onset of dementia is unclear. Objective: The aim of this systematic review and meta-analysis was to examine the relationship between loneliness and cognitive function in samples screened for dementia at study commencement. Methods: Five electronic databases (PubMed, PsycNET, Web of Science, EBSCOhost, Scopus) were searched from inception to August 31, 2021. A narrative review and random-effects meta-analysis were conducted on studies meeting search criteria. PROSPERO registration number: CRD42020155539. Results: The sixteen studies that met inclusion criteria involved 30,267 individuals, with mean age ranging from 63.0 to 84.9 years. Studies varied in dementia screening criteria, measurement of loneliness and cognitive function, and statistical modeling approach. The narrative review indicated that loneliness was associated with poorer global cognition, episodic memory, working memory, visuospatial function, processing speed, and semantic verbal fluency. Results of the meta-analysis indicated that loneliness was negatively associated with global cognitive function (overall r\u200a=\u200a\u20130.08; 95% CI\u200a=\u200a\u20130.14, \u20130.02; n\u200a=\u200a6). Due to lack of sufficient data and heterogeneity between studies, we were unable to explore associations with other cognitive domains or longitudinal associations. Conclusion: Loneliness is associated with subtle impairment across multiple cognitive domains in older adults who were screened for dementia. Better characterization of this relationship will provide important information about how loneliness contributes to the clinical and pathological sequalae of AD and be informative for risk reduction and early detection strategies.<\/jats:p>","DOI":"10.3233\/jad-220832","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T14:20:20Z","timestamp":1672755620000},"page":"1243-1259","source":"Crossref","is-referenced-by-count":80,"title":["Loneliness and Cognitive Function in Older Adults Without Dementia: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"91","author":[{"given":"Karra D.","family":"Harrington","sequence":"first","affiliation":[{"name":"Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shradha","family":"Vasan","sequence":"additional","affiliation":[{"name":"Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee eun","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA"},{"name":"Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Sliwinski","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA"},{"name":"Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle H.","family":"Lim","sequence":"additional","affiliation":[{"name":"Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Prevention Research Collaboration, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220832_ref2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer\u2019s disease facts and figures","volume":"18","author":"Alzheimer\u2019s Association","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-220832_ref3","unstructured":"National Academies of Sciences, Engineering, and Medicine (2020) Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System, National Academies Press, Washington, DC."},{"key":"10.3233\/JAD-220832_ref4","unstructured":"Perlman D , Peplau LA (1982) Theoretical approaches to loneliness. 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