{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:01:05Z","timestamp":1783479665254,"version":"3.55.0"},"reference-count":115,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,17]]},"abstract":"<jats:p>Background: Quadruple aberrant hyperphosphorylated tau, amyloid-\u03b2, \u03b1-synuclein, and TDP-43 pathology had been documented in 202\/203 forensic autopsies in Metropolitan Mexico City \u226440-year-olds with high exposures to ultrafine particulate matter and engineered nanoparticles. Cognition deficits, gait, equilibrium abnormalities, and MRI frontal, temporal, caudate, and cerebellar atrophy are documented in young adults. Objective: This study aimed to identify an association between falls, probable Rapid Eye Movement Sleep Behavior Disorder (pRBD), restless leg syndrome (RLS), and insomnia in 2,466 Mexican, college-educated volunteers (32.5\u00b112.4 years). Methods: The anonymous, online study applied the pRBD and RLS Single-Questions and self-reported night-time sleep duration, excessive daytime sleepiness, insomnia, and falls. Results: Fall risk was strongly associated with pRBD and RLS. Subjects who fell at least once in the last year have an OR\u200a=\u200a1.8137 [1.5352, 2.1426] of answering yes to pRBD and\/or RLS questions, documented in 29% and 24% of volunteers, respectively. Subjects fell mostly outdoors (12:01 pm to 6:00 pm), 43% complained of early wake up hours, and 35% complained of sleep onset insomnia (EOI). EOI individuals have an OR of 2.5971 [2.1408, 3.1506] of answering yes to the RLS question. Conclusion: There is a robust association between falls, pRBD, and RLS, strongly suggesting misfolded proteinopathies involving critical brainstem arousal and motor hubs might play a crucial role. Nanoparticles are likely a significant risk for falls, sleep disorders, insomnia, and neurodegenerative lethal diseases, thus characterizing air particulate pollutants\u2019 chemical composition, emission sources, and cumulative exposure concentrations are strongly recommended.<\/jats:p>","DOI":"10.3233\/jad-220850","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T13:17:55Z","timestamp":1670332675000},"page":"847-862","source":"Crossref","is-referenced-by-count":15,"title":["Fall Risk, Sleep Behavior, and Sleep-Related Movement Disorders in Young Urbanites Exposed to Air Pollution"],"prefix":"10.1177","volume":"91","author":[{"given":"Lilian","family":"Calder\u00f3n-Garcidue\u00f1as","sequence":"first","affiliation":[{"name":"The University of Montana, Missoula, MT, USA"},{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Kulesza","sequence":"additional","affiliation":[{"name":"Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen P.","family":"Greenough","sequence":"additional","affiliation":[{"name":"Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Garc\u00eda-Rojas","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Revueltas-Ficachi","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rico-Villanueva","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Orlando","family":"Flores-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Brito-Aguilar","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ram\u00edrez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Vacaseydel-Aceves","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital San Angel Inn Sur, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paulina","family":"Cortes-Flores","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, Mexico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013Head and Neck Surgery, Henry Ford Macomb Hospital, Clinton Township, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Torres-Jard\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias de la Atm\u00f3sfera y Cambio Clim\u00e1tico, Universidad Nacional, Aut\u00f3noma de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Villarreal-R\u00edos","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Piedras Negras, Piedras Negras, Coahuila, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Koseoglu","sequence":"additional","affiliation":[{"name":"Neurology Department, Erciyes University, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah W.","family":"Stommel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha S.","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Interdisciplinary Statistical Research Unit, Indian Statistical Institute, Kolkata, 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