{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:31:32Z","timestamp":1777426292906,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The correlation between plasma adipose factor levels and Alzheimer\u2019s patients is not entirely clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate associations between AD and plasma levels of three adipokines including plasma adiponectin, leptin, and resistin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A single-center, cross-sectional study recruited AD patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a148) and cognitively normal (CN) controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a110). The multivariate logistic regression analysis was applied to determine associations of adiponectin, leptin, and resistin with the presence of AD. The receiver operating characteristic (ROC) analysis was employed to determine the diagnostic power of adiponectin, leptin and resistin for AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After adjusted for the conventional risk factors, plasma levels of leptin (OR\u200a=\u200a0.417, 95% CI: 0.272-0.638,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001) and adiponectin (OR\u200a=\u200a1.249, 95% CI: 1.151-1.354,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001) were associated with the presence of AD. In total participants, the plasma adiponectin level was negatively correlated with MMSE scores (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001) and was positively with CDR scores (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001) and age (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001). The plasma level of leptin was negatively correlated with CDR scores (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001) and positively correlated with MMSE scores (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001). Both adiponectin (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0. 0001) and leptin (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0. 0001) featured higher AUC than the random chance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Plasma adiponectin and leptin were associated with the presence, symptomatic severity, and diagnostic power of AD, suggesting a potential role of adipokines in the pathogenesis of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-220860","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:43:20Z","timestamp":1696333400000},"page":"523-533","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Adipokines with Alzheimer\u2019s Disease in a Chinese Cohort"],"prefix":"10.1177","volume":"96","author":[{"given":"Cheng-Chun","family":"Liu","sequence":"first","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Yan","family":"Xin","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Wan","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yi","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Hua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China"},{"name":"University of Electronic Science and Technology of China","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["China"]},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 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