{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:39:29Z","timestamp":1777527569634,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Background: Virtually all adults with Down syndrome (DS) develop Alzheimer\u2019s disease (AD) pathology, but research gaps remain in understanding early signs of AD in DS. Objective: The goal of the present study was to determine if unintentional weight loss is part of AD in DS. The specific aims were to: 1) examine relation between chronological age, weight, AD pathology, and AD-related cognitive decline were assessed in a large cohort of adults with DS, and 2) determine if baseline PET amyloid-\u03b2 (A\u03b2) and tau PET status (\u2013versus+) and\/or decline in memory and mental status were associated with weight loss prior to AD progression. Methods: Analyses included 261 adults with DS. PET data were acquired using [11C] PiB for A\u03b2 and [18F] AV-1451 for tau. Body mass index (BMI) was calculated from weight and height. Direct measures assessed dementia and memory. Clinical AD status was determined using a case consensus process. Percent weight decline across 16\u201320 months was assessed in a subset of participants (n\u200a=\u200a77). Results: Polynomial regressions indicated an 0.23\u200akg\/m2 decrease in BMI per year beginning at age 36.5 years, which occurs alongside the period during which A\u03b2 and tau increase and memory and mental status decline. At a within-person level, elevated A\u03b2, decline in memory and mental status were associated with higher percent weight loss across 16\u201320 months. Conclusion: Unintentional weight loss occurs alongside A\u03b2 deposition and prior to onset of AD dementia, and thus may be a useful sign of AD in DS.<\/jats:p>","DOI":"10.3233\/jad-220865","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:56:16Z","timestamp":1671540976000},"page":"1215-1227","source":"Crossref","is-referenced-by-count":9,"title":["Weight Loss and Alzheimer\u2019s Disease in Down Syndrome"],"prefix":"10.1177","volume":"91","author":[{"given":"Victoria","family":"Fleming","sequence":"first","affiliation":[{"name":"Waisman Center, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"School of Human Ecology, University of Wisconsin-Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Alzheimer\u2019s Biomarker Consortium \u2013Down Syndrome (ABC-DS) Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Helsel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren T.","family":"Ptomey","sequence":"additional","affiliation":[{"name":"Departmentof Internal Medicine, University of Kansas Medical Center, KansasCity, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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