{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:02:39Z","timestamp":1789473759508,"version":"build-2803163510"},"reference-count":192,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common neurodegenerative disorder worldwide. Although the main cause of the onset and development of AD is not known yet, neuronal death due to pathologic changes such as amyloid-\u03b2 (A\u03b2) deposition, tau aggregation, neuroinflammation, oxidative stress, and calcium dyshomeostasis are considered to be the main cause. At the present, there is no cure for this insidious disorder. However, accurate identification of molecular changes in AD can help provide new therapeutic goals. Caspases are a group of proteases which are known because of their role in cellular apoptosis. In addition, different caspases are involved in other cellular responses to the environment, such as induction of inflammation. Emerging evidence suggest that these proteases play a central role in AD pathophysiology due to their role in the processing of amyloid-\u03b2 protein precursor, tau cleavage, and neuroinflammation. Therefore, it seems that targeting caspases may be a suitable therapeutic option to slow the progression of AD. This review focuses on the role of caspases in AD pathophysiology and introduce results from studies targeted caspases in different models of AD.<\/jats:p>","DOI":"10.3233\/jad-220873","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T11:08:06Z","timestamp":1669115286000},"page":"71-90","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Caspases in Alzheimer\u2019s Disease: Pathophysiology Implications and Pharmacologic Modulation"],"prefix":"10.1177","volume":"91","author":[{"given":"Mohammad Rafi","family":"Khezri","sequence":"first","affiliation":[{"name":"Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Ghasemnejad-Berenji","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran"},{"name":"Research Center for 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