{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:23:45Z","timestamp":1782516225951,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:p>Background: This longitudinal study addressed whether mindfulness practice prevents psychological and behavioral symptoms, especially mood disorders, in Alzheimer\u2019s disease (AD). Objective: To assess the incidence of depression in the course of AD and to determine which non-pharmacological treatment (NPT) is most effective in preventing psychopathological symptoms. Methods: We conducted a longitudinal, non-inferiority and equivalence randomized clinical trial, repeated-measures design, with a control group and three experimental treatments: mindfulness, cognitive stimulation, and relaxation. Each experimental group performed three weekly sessions for two years. The pharmacological treatment of all participants was donepezil (10\u200amg). Participants were patients with probable AD without diagnosed depression from the public neurology services of the Canary Health Service, Spain. Psychological evaluation was performed using the Geriatric Depression Scale (GDS), Hamilton Depression Rating Scale (HDRS), and Neuropsychiatric Inventory (NPI-Q). The statistical analysis included only patients who attended at least 75% of the sessions. A nonparametric, repeated-measures analysis was performed with Kruskal-Wallis H test and between-group differences with Mann-Whitney U test with Bonferroni correction (p\u200a&lt;\u200a0.008). Effect size was calculated with partial eta-squared. Results: The results showed significant differences with large effect sizes (\u03b72p&gt;0.14) between mindfulness and the rest of the experimental groups as well as the control in the GDS, HDRS, and NPI-Q scales. Conclusion: Compared to the other experimental groups, only mindfulness prevented the onset of depression and other psychopathologies in early-stage AD. Based on its effectiveness in maintaining cognitive functions and preventing psychopathology, we recommend mindfulness as the first-choice NPT for mild to moderate AD.<\/jats:p>","DOI":"10.3233\/jad-220889","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T09:59:53Z","timestamp":1669370393000},"page":"471-481","source":"Crossref","is-referenced-by-count":14,"title":["Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer\u2019s Disease: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"91","author":[{"given":"Domingo J.","family":"Quintana-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Psychology, Atl\u00e1ntico Medio University, Tafira Baja, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Rojas-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Canaria para el Desarrollo de la Salud a trav\u00e9s de la Atenci\u00f3n, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Santana-del Pino","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Las Palmas de Gran Canaria University, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"C\u00e9spedes Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Psychology, Atl\u00e1ntico Medio University, Tafira Baja, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Pellejero Silva","sequence":"additional","affiliation":[{"name":"Department of Communication, Atl\u00e1ntico Medio University, Tafira Baja, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Mir\u00f3-Barrachina","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Psychobiology and Methodology, La Laguna University, La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ib\u00e1\u00f1ez Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Psychobiology and Methodology, La Laguna University, La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Estupi\u00f1\u00e1n L\u00f3pez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Canaria para el Desarrollo de la Salud a trav\u00e9s de la Atenci\u00f3n, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas F.","family":"Borkel","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220889_ref1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3233\/JAD-220170","article-title":"Prevalence of depressive symptoms in a memory clinic cohort: A retrospective study","volume":"88","author":"Loreto","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-220889_ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2013.05.021","article-title":"Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer\u2019s disease","volume":"548","author":"Son","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-220889_ref3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1037\/0022-006X.68.4.615","article-title":"Prevention of relapse\/recurrence in major depression by mindfulness-based cognitive therapy","volume":"68","author":"Teasdale","year":"2000","journal-title":"J Consult Clin Psychol"},{"key":"10.3233\/JAD-220889_ref4","first-page":"377","article-title":"[Epidemiology of Alzheimer\u2019s disease and other dementias]","volume":"66","author":"Garre-Olmo","year":"2018","journal-title":"Rev Neurol"},{"key":"10.3233\/JAD-220889_ref5","doi-asserted-by":"crossref","unstructured":"Lopez OL , Kuller LH (2019) Chapter 9 - Epidemiology of aging and associated cognitive disorders: Prevalence and incidence of Alzheimer\u2019s disease and other dementias. 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