{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:07:56Z","timestamp":1777396076033,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:p>Background: Ankle-brachial index (ABI), an indicator of atherosclerosis or arterial stiffness, has been associated with Alzheimer\u2019s disease (AD) dementia and related cognitive impairment. Nevertheless, only limited information is available regarding its contribution to brain alterations leading to cognitive decline in late-life. Objective: We aimed to investigate the relationship of ABI with in vivo AD pathologies and cerebrovascular injury in cognitively impaired older adults. Methods: Total 127 cognitively impaired (70 mild cognitive impairment and 57 AD dementia) individuals, who participated in an ongoing prospective cohort study, were included. All participants underwent comprehensive clinical and neuropsychological assessment, ABI measurement, apolipoprotein E (APOE) \u025b4 genotyping, and multi-modal brain imaging including [11C] Pittsburgh Compound B (PiB)-positron emission tomography (PET) and [18F] fludeoxyglucose (FDG)-PET, and MRI. Results: General linear model analysis showed significant relationship between ABI strata (low ABI: &lt;1.00, normal ABI: 1.00\u20131.29, and high ABI: \u22651.30) and AD-signature region cerebral glucose metabolism (AD-CM), even after controlling age, sex, clinical dementia rating\u2013sum of box, and APOE \u025b4 positivity (p\u200a=\u200a0.029). Post hoc comparison revealed that low ABI had significantly lower AD-CM than middle and high ABI, while no difference of AD-CM was found between middle and high ABI. There was no significant difference of global A\u03b2 deposition, AD-signature region cortical thickness, and white matter hyperintensity volume between the three ABI strata. Conclusion: Our findings suggest that lower ABI, likely related to atherosclerosis, may contribute to the aggravation of AD-related regional neurodegeneration in cognitively impaired older adults.<\/jats:p>","DOI":"10.3233\/jad-220911","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:10:42Z","timestamp":1678795842000},"page":"87-95","source":"Crossref","is-referenced-by-count":2,"title":["Low Ankle-Brachial Index Relates to Alzheimer-Signature Cerebral Glucose Metabolism in Cognitively Impaired Older Adults"],"prefix":"10.1177","volume":"93","author":[{"given":"Seok Woo","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry & Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"and for the KBASE Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahyun","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Eulji University Nowon Eulji Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayeong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gijung","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koung Mi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Ho","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-220911_ref1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/ije\/17.2.248","article-title":"The measurement of atherosclerotic peripheral arterial-disease in epidemiological surveys","volume":"17","author":"Fowkes","year":"1988","journal-title":"Int J Epidemiol"},{"key":"10.3233\/JAD-220911_ref2","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1161\/CIRCULATIONAHA.106.686477","article-title":"Ankle-to-brachial index and dementia: The Honolulu-Asia Aging 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