{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:51Z","timestamp":1787025891086,"version":"build-2736575974"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:p>Background: Mild cognitive impairment (MCI) represents a high risk group for Alzheimer\u2019s disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive networks. Objective: The goal of this study was to examine the effect of CCT versus a non-targeted active brain exercise on functional cognitive networks. Methods: 107 patients with MCI were randomized to CCT or web-based crossword puzzles. Resting-state functional MRI (fMRI) was obtained at baseline and 18 months to evaluate differences in fMRI measured within- and between-network functional connectivity (FC) of the default mode network (DMN) and other large-scale brain networks: the executive control, salience, and sensorimotor networks. Results: There were no differences between crosswords and games in the primary outcome, within-network DMN FC across all subjects. However, secondary analyses suggest differential effects on between-network connectivity involving the DMN and SLN, and within-network connectivity of the DMN in subjects with late MCI. Paradoxically, in both cases, there was a decrease in FC for games and an increase for the crosswords control (p\u200a&lt;\u200a0.05), accompanied by lesser cognitive decline in the crosswords group. Conclusion: Results do not support a differential impact on within-network DMN FC between games and crossword puzzle interventions. However, crossword puzzles might result in cognitively beneficial remodeling between the DMN and other networks in more severely impaired MCI subjects, parallel to the observed clinical benefits.<\/jats:p>","DOI":"10.3233\/jad-220946","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T10:00:04Z","timestamp":1669370404000},"page":"483-494","source":"Crossref","is-referenced-by-count":23,"title":["Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer\u2019s Disease: A\u00a078-week Randomized Controlled Trial"],"prefix":"10.1177","volume":"91","author":[{"given":"Jeffrey R.","family":"Petrella","sequence":"first","affiliation":[{"name":"Department of Radiology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Michael","sequence":"additional","affiliation":[{"name":"Duke Institute for Brain Sciences and the Duke Center for the Study of Aging and Human Development, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaora","family":"Nwosu","sequence":"additional","affiliation":[{"name":"Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Sneed","sequence":"additional","affiliation":[{"name":"Department of Psychology, Queens College, City University of New York, Flushing, NY, USA"},{"name":"Department of Psychology The Graduate Center, City University of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry E.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davangere P.","family":"Devanand","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, and the New York Psychiatry Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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