{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:15:16Z","timestamp":1777396516618,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pre-symptomatic screening methods for detecting a higher risk of Alzheimer\u2019s disease (AD) are gaining popularity; thus, more people are seeking these tests. However, to date, not much is known about the attitudes toward pre-symptomatic AD screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The goal of this study is to examine the psychometric properties of a tool for assessing the attitudes, barriers, and motivations to pre-symptomatic AD screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a cross-sectional study performed on 208 Greek participants (189 students and 19 caregivers) provided with an online questionnaire. Psychometric properties were assessed through the examination of its construct validity (principal component analysis) and internal consistency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Exploratory factor analysis revealed the presence of four factors. The first factor is labeled as \u201cPerceived harms of testing\u201d (10 items), the second \u201cAcceptance of testing\u201d (5 items), the third \u201cPerceived benefits of testing\u201d (6 items), and the fourth factor \u201cNeed for knowledge\u201d (4 items). The reliability (internal consistency) of each factor separately was acceptable to good (0.70\u20130.87) while the internal consistency of the overall questionnaire (25 items) was good (Cronbach\u2019s \u03b1=0.82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PRE-ADS is a valid questionnaire that might help in the research of peoples\u2019 attitudes related to the pros and cons of pre-symptomatic screening for AD, and the development of effective counseling programs and prevention strategies. However, future research is required in the target population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-220954","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:25:36Z","timestamp":1693567536000},"page":"1163-1174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Attitudes, Motivations, and Barriers to Pre-Symptomatic Alzheimer\u2019s Disease Screening: Development and Validation of the \u2018Perceptions regarding pRE-symptomatic Alzheimer\u2019s Disease Screening\u2019 (PRE-ADS) Questionnaire"],"prefix":"10.1177","volume":"95","author":[{"given":"Marina","family":"Makri","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"},{"name":"Greek Association of Alzheimer Disease and Related Disorders, Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI \u2013 AUTh), Balkan Center, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Gkioka","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI \u2013 AUTh), Balkan Center, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Moraitou","sequence":"additional","affiliation":[{"name":"Department of Experimental and Cognitive Psychology, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative 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Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalini","family":"Tsolaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"},{"name":"Greek Association of Alzheimer Disease and Related Disorders, Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI \u2013 AUTh), Balkan Center, Aristotle University of Thessaloniki, Thessaloniki, 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