{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:58:14Z","timestamp":1780775894102,"version":"3.54.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:p>Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and \u223c10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.<\/jats:p>","DOI":"10.3233\/jad-220998","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T11:36:42Z","timestamp":1702381002000},"page":"163-170","source":"Crossref","is-referenced-by-count":8,"title":["Patterns of Aging Changes in Bodyweight May Predict Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"97","author":[{"given":"Svetlana","family":"Ukraintseva","sequence":"first","affiliation":[{"name":"Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhe","family":"Duan","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, 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