{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:10:51Z","timestamp":1780625451722,"version":"3.54.1"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:p>Background: Preclinical Alzheimer\u2019s disease (AD) is one possible cause of subjective cognitive decline (SCD). Normal task performance despite ongoing neurodegeneration is typically considered as neuronal compensation, which is reflected by greater neuronal activity. Compensatory brain activity has been observed in frontal as well as parietal regions in SCD, but data are scarce, especially outside the memory domain. Objective: To investigate potential compensatory activity in SCD. Such compensatory activity is particularly expected in participants where blood-based biomarkers indicated amyloid positivity as this implies preclinical AD. Methods: 52 participants with SCD (mean age: 71.00\u00b15.70) underwent structural and functional neuroimaging (fMRI), targeting episodic memory and spatial abilities, and a neuropsychological assessment. The estimation of amyloid positivity was based on plasma amyloid-\u03b2 and phosphorylated tau (pTau181) measures. Results: Our fMRI analyses of the spatial abilities task did not indicate compensation, with only three voxels exceeding an uncorrected threshold at p\u200a&lt;\u200a0.001. This finding was not replicated in a subset of 23 biomarker positive individuals. Conclusion: Our results do not provide conclusive evidence for compensatory brain activity in SCD. It is possible that neuronal compensation does not manifest at such an early stage as SCD. Alternatively, it is possible that our sample size was too small or that compensatory activity may be too heterogeneous to be detected by group-level statistics. Interventions based on the individual fMRI signal should therefore be explored.<\/jats:p>","DOI":"10.3233\/jad-221001","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T12:24:22Z","timestamp":1679401462000},"page":"107-124","source":"Crossref","is-referenced-by-count":8,"title":["Investigating Compensatory Brain Activity in Older Adults with Subjective Cognitive Decline"],"prefix":"10.1177","volume":"93","author":[{"given":"Christine","family":"Krebs","sequence":"first","affiliation":[{"name":"University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland"},{"name":"Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Brill","sequence":"additional","affiliation":[{"name":"University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland"},{"name":"Swiss Institute for 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patric","family":"Wyss","sequence":"additional","affiliation":[{"name":"University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Vrije University, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argonde C.","family":"van Harten","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Seydell-Greenwald","sequence":"additional","affiliation":[{"name":"Center for Brain Plasticity and Recovery, Georgetown 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