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Aging and ApoE4, the two most important risk factors for Alzheimer\u2019s disease (AD), induce mLV dysfunction, decrease cerebrospinal fluid influx and outflux, and exacerbate amyloid pathology and cognitive dysfunction. Dysfunction of mLVs results in the deposition of metabolic products, accelerates neuroinflammation, and promotes the release of pro-inflammatory cytokines in the brain. Thus, mLVs represent a novel therapeutic target for treating neurodegenerative and neuroinflammatory diseases. This review aims to summarize the structure and function of mLVs and to discuss the potential effect of aging and ApoE4 on mLV dysfunction, as well as their roles in the pathogenesis of AD.<\/jats:p>","DOI":"10.3233\/jad-221016","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T10:52:55Z","timestamp":1674211975000},"page":"S355-S366","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"94","author":[{"given":"Xiaodi","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 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