{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:54:17Z","timestamp":1781855657615,"version":"3.54.5"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,6,13]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To describe structural and functional changes in insula subregions in asymptomatic carriers of the P301L mutation of the microtubule-associated protein tau (\n                      <jats:italic toggle=\"yes\">MAPT<\/jats:italic>\n                      ) gene and patients with bvFTD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Six asymptomatic\n                      <jats:italic toggle=\"yes\">MAPT<\/jats:italic>\n                      P301L mutation carriers and 12\n                      <jats:italic toggle=\"yes\">MAPT<\/jats:italic>\n                      negative control subjects of the same pedigree were enrolled, along with 30 patients with a clinical diagnosis of bvFTD and 30 matched controls. All subjects underwent hybrid positron emission tomography\/magnetic resonance imaging. Atlas-based parcellation using a fine-grained Brainnetome Atlas was conducted to assess gray matter (GM) volume, metabolism, and metabolic connectivity in the sub-insula (region of interest).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was no significant GM atrophy or hypometabolism in insula subregions in asymptomatic\n                      <jats:italic toggle=\"yes\">MAPT<\/jats:italic>\n                      P301L carriers, although decreased metabolic connectivity between vIa-middle temporal gyrus, vIa-temporal poles, dIa-middle temporal gyrus and dIa-temporal poles; and increased connectivity between vIa-orbitofrontal, vIa-dorsal lateral superior frontal gyrus, and dIa-orbitofrontal and dIa-dorsal lateral superior frontal gyrus were observed. Patients with bvFTD had significant atrophy and hypometabolism in all insula subregions and decreased metabolic connectivity in the whole brain, including vIa\/dIa-middle temporal and vIa\/dIa-temporal poles. The standardized uptake value ratios of vIa and dIa were negatively associated with Frontal behavior inventory disinhibition scale scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Metabolic connectivity is altered in vIa and dIa subregions of the sub-insula in\n                      <jats:italic toggle=\"yes\">MAPT<\/jats:italic>\n                      P301L mutation carriers before the occurrence of atrophy, hypometabolism, and clinical symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-221035","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T13:39:43Z","timestamp":1683898783000},"page":"1369-1380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered Anterior Insular Metabolic Connectivity in Asymptomatic\n                    <i>MAPT<\/i>\n                    P301L Carriers"],"prefix":"10.1177","volume":"93","author":[{"given":"Min","family":"Chu","sequence":"first","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of High Energy Physics","place":["China"]},{"name":"University of Chinese Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cui","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Research Unit","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Wu","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430617"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02440-1"},{"issue":"1","key":"e_1_3_3_6_2","first-page":"S65","article-title":"Frontotemporal dementia: An updated overview","volume":"51","author":"Mohandas E","year":"2009","unstructured":"MohandasE, RajmohanV (2009) Frontotemporal dementia: An updated overview. 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