{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:44:21Z","timestamp":1787877861024,"version":"build-2784847793"},"reference-count":59,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,10,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is associated with an increased risk of amyloid-\u03b2 (A\u03b2) burden, the hallmark of Alzheimer\u2019s disease, and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the differential impacts of hypoxemia and slow-wave sleep disruption on brain amyloid burden, and to explore the effects of hypoxemia, slow-wave sleep disruption, and amyloid burden on cognition in individuals with and without OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-four individuals with confirmed OSA (mean\u00b1SD age 57.5\u00b14.1 years; 19 males) and 12 healthy controls (58.5\u00b14.2 years; 6 males) underwent a clinical polysomnogram, a NAV4694 positron emission tomography (PET) scan for A\u03b2 burden, assessment of APOE \u025b status and cognitive assessments. Linear hierarchical regressions were conducted to determine the contributions of demographic and sleep variables on amyloid burden and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A\u03b2 burden was associated with nocturnal hypoxemia, and impaired verbal episodic memory, autobiographical memory and set shifting. Hypoxemia was correlated with impaired autobiographical memory, and only set shifting performance remained significantly associated with A\u03b2 burden when controlling for sleep variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Nocturnal hypoxemia was related to brain A\u03b2 burden in this sample of OSA participants. A\u03b2 burden and hypoxemia had differential impacts on cognition. This study reveals aspects of sleep disturbance in OSA that are most strongly associated with brain A\u03b2 burden and poor cognition, which are markers of early Alzheimer\u2019s disease. These findings add weight to the possibility that hypoxemia may be causally related to the development of dementia; however, whether it may be a therapeutic target for dementia prevention in OSA is yet to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-221049","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:41:57Z","timestamp":1695382917000},"page":"149-159","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Associations Between Amyloid Burden, Hypoxemia, Sleep Architecture, and Cognition in Obstructive Sleep Apnea"],"prefix":"10.1177","volume":"96","author":[{"given":"Marina G.","family":"Cavuoto","sequence":"first","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia"},{"name":"Institute for Breathing and Sleep, Austin Health, Heidelberg, 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