{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:11:59Z","timestamp":1792512719026,"version":"4.5.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>Background: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and blood-brain barrier (BBB) impairment in vascular dementia (VaD). However, the relationship and the molecular mechanisms between BBB dysfunction and neuronal loss remain elusive. Objective: We explored the reasons for neuron loss following CCH. Methods: Using permanent bilateral common carotid artery occlusion (2VO) rat model, we observed the pathological changes of cortical neurons and BBB in the sham group as well as rats 3d, 7d, 14d and 28d post 2VO. In order to further explore the factors influencing neuron loss following CCH with regard to cortical blood vessels, we extracted cortical brain microvessels at five time points for transcriptome sequencing. Finally, integrin receptor a4\u03b21 (VLA-4) inhibitor was injected into the tail vein, and cortical neuron loss was detected again. Results: We found that cortical neuron loss following CCH is a continuous process, but damage to the BBB is acute and transient. Results of cortical microvessel transcriptome analysis showed that biological processes related to vascular inflammation mainly occurred in the chronic phase. Meanwhile, cell adhesion molecules, cytokine-cytokine receptor interaction were significantly changed at this phase. Among them, the adhesion molecule VCAM1 plays an important role. Using VLA-4 inhibitor to block VCAM1-VLA-4 interaction, cortical neuron damage was ameliorated at 14d post 2VO. Conclusion: Injury of the BBB may not be the main reason for persistent loss of cortical neurons following CCH. The continuous inflammatory response within blood vessels maybe an important factor in the continuous loss of cortical neurons following CCH.<\/jats:p>","DOI":"10.3233\/jad-221059","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T12:29:52Z","timestamp":1673612992000},"page":"1541-1555","source":"Crossref","is-referenced-by-count":11,"title":["VCAM1 Drives Vascular Inflammation Leading to Continuous Cortical Neuronal Loss Following Chronic Cerebral Hypoperfusion"],"prefix":"10.1177","volume":"91","author":[{"given":"Ruihua","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"},{"name":"Department of Neurology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkui","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingran","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"},{"name":"Department of Neurology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"},{"name":"Department of Neurology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"},{"name":"Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"},{"name":"Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"},{"name":"Department of Neurology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-221059_ref1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/S0140-6736(99)04016-7","article-title":"Volume reduction in cerebral blood flow in patients with vascular dementia","volume":"354","author":"Scheel","year":"1999","journal-title":"Lancet"},{"key":"10.3233\/JAD-221059_ref2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.arr.2011.12.009","article-title":"Cerebrovascular hemodynamics in Alzheimer\u2019s disease and vascular dementia: A meta-analysis of transcranial Doppler studies","volume":"11","author":"Sabayan","year":"2012","journal-title":"Ageing Res Rev"},{"key":"10.3233\/JAD-221059_ref3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","article-title":"Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam Study","volume":"57","author":"Ruitenberg","year":"2005","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-221059_ref4","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.neuron.2019.01.014","article-title":"Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer\u2019s disease model","volume":"101","author":"Merlini","year":"2019","journal-title":"Neuron"},{"key":"10.3233\/JAD-221059_ref5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1083\/jcb.34.1.207","article-title":"Fine structural localization of a blood-brain barrier to exogenous peroxidase","volume":"34","author":"Reese","year":"1967","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-221059_ref6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"10.3233\/JAD-221059_ref7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.3233\/JAD-221059_ref8","doi-asserted-by":"crossref","first-page":"e20190062","DOI":"10.1084\/jem.20190062","article-title":"The blood-brain barrier in health and disease: Important unanswered questions","volume":"217","author":"Profaci","year":"2020","journal-title":"J Exp Med"},{"key":"10.3233\/JAD-221059_ref9","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.apsb.2020.02.015","article-title":"TIMP1 preserves the blood-brain barrier through interacting with CD63\/integrin \u03b2 1 complex and regulating downstream FAK\/RhoA signaling","volume":"10","author":"Tang","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.3233\/JAD-221059_ref10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12987-021-00255-2","article-title":"Reduction in pericyte coverage leads to blood-brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion","volume":"18","author":"Sun","year":"2021","journal-title":"Fluids Barriers CNS"},{"key":"10.3233\/JAD-221059_ref11","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1038\/s41380-020-00971-5","article-title":"AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia","volume":"26","author":"Poh","year":"2021","journal-title":"Mol Psychiatr"},{"key":"10.3233\/JAD-221059_ref12","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/brain\/113.5.1477","article-title":"Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications","volume":"113","author":"Kermode","year":"1990","journal-title":"Brain"},{"key":"10.3233\/JAD-221059_ref13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ana.410340507","article-title":"Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis","volume":"34","author":"Katz","year":"1993","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-221059_ref14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1023\/A:1021067822435","article-title":"Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats","volume":"22","author":"Abrah\u00e1m","year":"2002","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-221059_ref15","first-page":"463","article-title":"Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model","volume":"10","author":"Ujiie","year":"2003","journal-title":"Microcirculation"},{"key":"10.3233\/JAD-221059_ref16","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1161\/STROKEAHA.107.491621","article-title":"Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats","volume":"38","author":"Lee","year":"2007","journal-title":"Stroke"},{"key":"10.3233\/JAD-221059_ref17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neurobiolaging.2006.12.007","article-title":"Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats","volume":"29","author":"DiNapoli","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-221059_ref18","doi-asserted-by":"crossref","first-page":"e1669","DOI":"10.1212\/WNL.0000000000007263","article-title":"Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease","volume":"92","author":"Wong","year":"2019","journal-title":"Neurology"},{"key":"10.3233\/JAD-221059_ref19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jocn.2020.01.026","article-title":"Chronic cerebral hypoperfusion: An undefined, relevant entity","volume":"73","author":"Ciacciarelli","year":"2020","journal-title":"J Clin Neurosci"},{"key":"10.3233\/JAD-221059_ref20","doi-asserted-by":"crossref","first-page":"616236","DOI":"10.3389\/fncel.2020.616236","article-title":"Corrigendum: Comprehensive evaluation of white matter damage and neuron death and whole-transcriptome analysis of rats with chronic cerebral hypoperfusion","volume":"14","author":"Li","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.3233\/JAD-221059_ref21","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0092-8674(95)90491-3","article-title":"Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow","volume":"80","author":"Berlin","year":"1995","journal-title":"Cell"},{"key":"10.3233\/JAD-221059_ref22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1189\/jlb.0710432","article-title":"Vascular inflammation in central nervous system diseases: Adhesion receptors controlling leukocyte-endothelial interactions","volume":"89","author":"Rossi","year":"2011","journal-title":"J Leukoc Biol"},{"key":"10.3233\/JAD-221059_ref23","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1083\/jcb.128.6.1243","article-title":"The integrin VLA-4 supports tethering and rolling in flow on VCAM-1","volume":"128","author":"Alon","year":"1995","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-221059_ref24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.3233\/JAD-221059_ref25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.3233\/JAD-221059_ref26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-221059_ref27","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/nm.1878","article-title":"A role for leukocyte-endothelial adhesion mechanisms in epilepsy","volume":"14","author":"Fabene","year":"2008","journal-title":"Nat Med"},{"key":"10.3233\/JAD-221059_ref28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0967-5868(98)90069-8","article-title":"Long-term potentiation saturation in chronic cerebral hypoperfusion","volume":"5","author":"Sekhon","year":"1998","journal-title":"J Clin Neurosci"},{"key":"10.3233\/JAD-221059_ref29","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/VHRM.S2608","article-title":"Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer\u2019s disease","volume":"4","author":"Aliev","year":"2008","journal-title":"Vasc Health Risk Man"},{"key":"10.3233\/JAD-221059_ref30","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/jcbfm.2008.91","article-title":"Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review","volume":"28","author":"Hainsworth","year":"2008","journal-title":"J Cerebr Blood Flow Metab"},{"key":"10.3233\/JAD-221059_ref31","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/ene.12138","article-title":"Assessment of cognitive function in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization","volume":"20","author":"Su","year":"2013","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-221059_ref32","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.jocn.2013.12.032","article-title":"Cognitive function, depression, anxiety and quality of life in Chinese patients with untreated unruptured intracranial aneurysms","volume":"21","author":"Su","year":"2014","journal-title":"J Clin Neurosci"},{"key":"10.3233\/JAD-221059_ref33","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.neuroscience.2015.03.021","article-title":"Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling","volume":"301","author":"Su","year":"2015","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-221059_ref34","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbr.2016.07.009","article-title":"Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K\/AKT signaling","volume":"313","author":"Su","year":"2016","journal-title":"Behav Brain Res"},{"key":"10.3233\/JAD-221059_ref35","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00210-017-1417-9","article-title":"Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-\u03baB pathways","volume":"390","author":"Su","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.3233\/JAD-221059_ref36","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/STROKEAHA.111.620179","article-title":"Synergistic memory impairment through the interaction of chronic cerebral hypoperfusion and amyloid toxicity in a rat model","volume":"42","author":"Choi","year":"2011","journal-title":"Stroke"},{"key":"10.3233\/JAD-221059_ref37","doi-asserted-by":"crossref","first-page":"031411","DOI":"10.1117\/1.NPh.3.3.031411","article-title":"Cerebral blood flow and autoregulation: Current measurement techniques and prospects for noninvasive optical methods","volume":"3","author":"Fantini","year":"2016","journal-title":"Neurophotonics"},{"key":"10.3233\/JAD-221059_ref38","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3233\/JAD-2010-091699","article-title":"Arterial spin labeling blood flow MRI: Its role in the early characterization of Alzheimer\u2019s disease","volume":"20","author":"Alsop","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-221059_ref39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/WAD.0b013e3181b4f736","article-title":"ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia","volume":"24","author":"Chao","year":"2010","journal-title":"Alzheimers Dis Assoc Dis"},{"key":"10.3233\/JAD-221059_ref40","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1073\/pnas.92.5.1426","article-title":"Plasma albumin is a potent trigger of calcium signals and DNA synthesis in astrocytes","volume":"92","author":"Nadal","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-221059_ref41","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0166-2236(00)01617-9","article-title":"Serine proteases and brain damage \u2013 is there a link?","volume":"23","author":"Gingrich","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.3233\/JAD-221059_ref42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1212\/WNL.59.3.321","article-title":"Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis","volume":"59","author":"O\u2019Sullivan","year":"2002","journal-title":"Neurology"},{"key":"10.3233\/JAD-221059_ref43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12868-018-0465-5","article-title":"Neurovascular dysfunction in vascular dementia, Alzheimer\u2019s and atherosclerosis","volume":"19","author":"Shabir","year":"2018","journal-title":"BMC Neurosci"},{"key":"10.3233\/JAD-221059_ref44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/brainsci6010006","article-title":"The effects of hypoxia and inflammation on synaptic signaling in the CNS","volume":"6","author":"Mukandala","year":"2016","journal-title":"Brain Sci"},{"key":"10.3233\/JAD-221059_ref45","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00004647-200006000-00009","article-title":"Inflammatory activation of human brain endothelial cells by hypoxic astrocytes in vitro is mediated by IL-1beta","volume":"20","author":"Zhang","year":"2000","journal-title":"J Cerebr Blood Flow Metab"},{"key":"10.3233\/JAD-221059_ref46","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1172\/JCI116778","article-title":"Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells","volume":"92","author":"Marui","year":"1993","journal-title":"J Clin Invest"},{"key":"10.3233\/JAD-221059_ref47","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/01.ATV.14.10.1665","article-title":"Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals","volume":"14","author":"Weber","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.3233\/JAD-221059_ref48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/187152812800958960","article-title":"Inhaled KMUP-1 prevents allergic pulmonary vascular inflammation and remodeling via NO and suppressed MMP-9 and ICAM-1\/VCAM-1","volume":"11","author":"Liu","year":"2012","journal-title":"Inflamm Allergy Drug Targets"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-221059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:09Z","timestamp":1777370829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-221059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":48,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-221059","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]}}}