{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:32:32Z","timestamp":1791952352050,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient\u2019s cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-\u03b2 42\/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.<\/jats:p>","DOI":"10.3233\/jad-221065","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:56:45Z","timestamp":1671541005000},"page":"915-922","source":"Crossref","is-referenced-by-count":30,"title":["A 19-Year-Old Adolescent with Probable Alzheimer\u2019s Disease1"],"prefix":"10.1177","volume":"91","author":[{"given":"Jianping","family":"Jia","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, P.R. 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