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Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n\u200a=\u200a12), MCI with remitted MDD (MDD+MCI) (n\u200a=\u200a12), and remitted MDD alone (MDD) (n\u200a=\u200a7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers.<\/jats:p>","DOI":"10.3233\/jad-221097","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T12:28:02Z","timestamp":1678451282000},"page":"1219-1227","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"92","author":[{"given":"Angela C.","family":"Golas","sequence":"first","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the PACt-MD Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Salwierz","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek K.","family":"Rajji","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Toronto Dementia Research Alliance, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Bowie","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Psychology, Queen\u2019s University, Kingston, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryl A.","family":"Butters","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Keenan Research Centre for Biomedical Science, St. Michael\u2019s Hospital, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair J.","family":"Flint","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"University Health Network, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foad","family":"Taghdiri","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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