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However, no study has investigated AERP measures in individuals with subjective memory complaints (SMCs), who have been suggested to be at a pre-clinical stage of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigated whether AERPs in older adults with SMC can be used to objectively identify those at high risk of developing AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      AERPs were measured in older adults. Presence of SMC was determined using the Memory Assessment Clinics Questionnaire (MAC-Q). Hearing thresholds using pure-tone audiometry, neuropsychological data, levels of amyloid-\u03b2 burden and Apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE)<\/jats:italic>\n                      <jats:italic toggle=\"yes\">\u025b<\/jats:italic>\n                      genotype were also obtained A classic two-tone discrimination (oddball) paradigm was used to elicit AERPs (i.e., P50, N100, P200, N200, and P300).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-two individuals (14 male, mean age 71.9\u00b15.2 years) participated in this study, of which, 43 (11 male, mean age 72.4\u00b15.5 years) were SMC and 19 (3 male, mean age 70.8\u00b14.3 years) were non-SMC (controls). P50 latency was weakly but significantly correlated with MAC-Q scores. In addition, P50 latencies were significantly longer in A\u03b2+ individuals compared to A\u03b2\u2013 individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Results suggest that P50 latencies may be a useful tool to identify individuals at higher risk (i.e., participants with high A\u03b2 burden) of developing measurable cognitive decline. Further longitudinal and cross-sectional studies in a larger cohort on SMC individuals are warranted to determine if AERP measures could be of significance for the detection of pre-clinical AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-221119","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T11:47:00Z","timestamp":1676980020000},"page":"1093-1109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Auditory Event-Related Potentials in Older Adults with Subjective Memory Complaints"],"prefix":"10.1177","volume":"92","author":[{"given":"Hadeel Y.","family":"Tarawneh","sequence":"first","affiliation":[{"name":"The University of Western Australia","place":["Australia"]},{"name":"Ear Science Institute Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dona M.P.","family":"Jayakody","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia","place":["Australia"]},{"name":"The University of Western Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipra","family":"Verma","sequence":"additional","affiliation":[{"name":"Fiona Stanley and Fremantle Hospital","place":["Australia"]},{"name":"Fiona Stanley and Royal Perth Hospital","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"The Australian e-Health Research Centre","place":["Australia"]},{"name":"Department of Molecular Imaging &amp; Therapy, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[{"name":"The Australian e-Health Research Centre","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmina H.A.M.","family":"Mulders","sequence":"additional","affiliation":[{"name":"The University of Western Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University","place":["Australia"]},{"name":"Macquarie University","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Edith Cowan University","place":["Australia"]},{"name":"Macquarie University","place":["Australia"]},{"name":"Murdoch University","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.02.001"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3740461"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612461679"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_6_9_2","first-page":"1075","article-title":"The neuropathological changes associated with normal brain aging","volume":"11","author":"Hof PR","year":"1996","unstructured":"HofPR, GlannakopoulosP, BourasC (1996) The neuropathological changes associated with normal brain aging. 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