{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:08:14Z","timestamp":1777396094568,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:p>Background: Altered social behavior is one of the symptoms of Alzheimer\u2019s disease (AD) that results in social withdrawal and loneliness and provides a major burden on patients and their relatives. Furthermore, loneliness is associated with an increased risk to develop AD and related dementias. Objective: We aimed to investigate if altered social behavior is an early indicator of amyloid-\u03b2 (A\u03b2) pathology in J20 mice, and if co-housing with wild type (WT) mice can positively influence this social phenotype. Methods: The social phenotype of group-housed mice was assessed using an automated behavioral scoring system for longitudinal recordings. Female mice were housed in a same-genotype (4 J20 or WT mice per colony) or mixed-genotype (2 J20 mice + 2 WT mice) colony. At 10 weeks of age, their behavior was assessed for five consecutive days. Results: J20 mice showed increased locomotor activity and social sniffing, and reduced social contact compared to WT mice housed in same-genotype colonies. Mixed-genotype housing reduced the social sniffing duration of J20 mice, increased social contact frequency of J20 mice, and increased nest hide by WT mice. Conclusion: Thus, altered social behavior can be used as an early indicator of A\u03b2-pathology in female J20 mice. Additionally, when co-housed with WT mice, their social sniffing phenotype is not expressed and their social contact phenotype is reduced. Our findings highlight the presence of a social phenotype in the early stages of AD and indicate a role for social environment variation in the expression of social behavior of WT and J20 mice.<\/jats:p>","DOI":"10.3233\/jad-221126","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:33:44Z","timestamp":1679661224000},"page":"211-224","source":"Crossref","is-referenced-by-count":3,"title":["Variation in Group Composition Alters an Early-Stage Social Phenotype in hAPP-Transgenic J20 Mice"],"prefix":"10.1177","volume":"93","author":[{"given":"Suzanne D.","family":"Lanooij","sequence":"first","affiliation":[{"name":"Groningen Institute for Evolutionary Life Sciences (GELIFES), Neurobiology, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich L.M.","family":"Eisel","sequence":"additional","affiliation":[{"name":"Groningen Institute for Evolutionary Life Sciences (GELIFES), Neurobiology, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddy A.","family":"van der Zee","sequence":"additional","affiliation":[{"name":"Groningen Institute for Evolutionary Life Sciences (GELIFES), Neurobiology, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martien J.H.","family":"Kas","sequence":"additional","affiliation":[{"name":"Groningen Institute for Evolutionary Life Sciences (GELIFES), Neurobiology, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-221126_ref1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3233\/JAD-2010-091624","article-title":"Modifiable lifestyle risk factors for Alzheimer\u2019s disease","volume":"20","author":"Flicker","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-221126_ref2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41582-018-0070-3","article-title":"Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease","volume":"14","author":"Kivipelto","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-221126_ref3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer\u2019s disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"10.3233\/JAD-221126_ref4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/gps.5065","article-title":"Social networks and loneliness in people with Alzheimer\u2019s dementia","volume":"34","author":"Balouch","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-221126_ref5","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3233\/JAD-180439","article-title":"The association between social engagement, loneliness, and risk of dementia: A systematic review and meta-analysis","volume":"66","author":"Penninkilampi","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-221126_ref6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/geronb\/gbz139","article-title":"Loneliness increases the risk of all-cause dementia and alzheimer\u2019s disease","volume":"75","author":"Sundstr\u00f6m","year":"2020","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10.3233\/JAD-221126_ref7","doi-asserted-by":"crossref","first-page":"E1337","DOI":"10.1212\/WNL.0000000000200039","article-title":"Association of loneliness with 10-year dementia risk and early markers of vulnerability for neurocognitive decline","volume":"98","author":"Salinas","year":"2022","journal-title":"Neurology"},{"key":"10.3233\/JAD-221126_ref8","doi-asserted-by":"crossref","first-page":"pyu116","DOI":"10.1093\/ijnp\/pyu116","article-title":"Isolation housing exacerbates Alzheimer\u2019s disease- like pathophysiology in aged APP\/PS1 mice","volume":"18","author":"Huang","year":"2015","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.3233\/JAD-221126_ref9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fneur.2012.00073","article-title":"Behavioral and psychological symptoms of dementia","volume":"3","author":"Cerejeira","year":"2012","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-221126_ref10","doi-asserted-by":"crossref","first-page":"580609","DOI":"10.3389\/fnagi.2020.580609","article-title":"Face recognition deficits in a patient with Alzheimer\u2019s disease: Amnesia or agnosia? 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