{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:57:30Z","timestamp":1787507850934,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,6,13]]},"abstract":"<jats:p>Background: Metabolic asymmetry has been observed in Alzheimer\u2019s disease (AD), but different studies have inconsistent viewpoints. Objective: To analyze the asymmetry of cerebral glucose metabolism in AD and investigate its clinical significance and potential metabolic network abnormalities. Methods: Standardized uptake value ratios (SUVRs) were obtained from 18F-FDG positron emission tomography (PET) images of all participants, and the asymmetry indices (AIs) were calculated according to the SUVRs. AD group was divided into left\/right-dominant or bilateral symmetric hypometabolism (AD-L\/AD-R or AD-BI) when more than half of the AIs of the 20 regions of interest (ROIs) were &lt; \u20132SD, &gt;2SD, or between\u00b11SD. Differences in clinical features among the three AD groups were compared, and the abnormal network characteristics underlying metabolic asymmetry were explored. Results: In AD group, the proportions of AD-L, AD-R, and AD-BI were 28.4%, 17.9%, and 18.5%, respectively. AD-L\/AD-R groups had younger age of onset and faster rate of cognitive decline than AD-BI group (p\u200a&lt;\u200a0.05). The absolute values of AIs in half of the 20 ROIs became higher at follow-up than at baseline (p\u200a&lt;\u200a0.05). Compared with those in AD-BI group, metabolic connection strength of network, global efficiency, cluster coefficient, degree centrality and local efficiency were lower, but shortest path length was longer in AD-L and AD-R groups (p\u200a&lt;\u200a0.05). Conclusion: Asymmetric and symmetric hypometabolism may represent different clinical subtypes of AD, which may provide a clue for future studies on the heterogeneity of AD and help to optimize the design of clinical trials.<\/jats:p>","DOI":"10.3233\/jad-221258","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T13:39:54Z","timestamp":1683898794000},"page":"1395-1406","source":"Crossref","is-referenced-by-count":10,"title":["Metabolic Asymmetry Relates to Clinical Characteristics and Brain Network Abnormalities in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"93","author":[{"given":"Huamei","family":"Lin","sequence":"first","affiliation":[{"name":"Deparment of Nuclear Medicine \/ PET Center, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[{"name":"Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High EnergyPhysics, Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Ge","sequence":"additional","affiliation":[{"name":"Deparment of Nuclear Medicine \/ PET Center, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 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Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Deparment of Nuclear Medicine \/ PET Center, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[{"name":"Deparment of Nuclear Medicine \/ PET Center, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoci","family":"Shan","sequence":"additional","affiliation":[{"name":"Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High EnergyPhysics, Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-1218","authenticated-orcid":false,"given":"Binbin","family":"Nie","sequence":"additional","affiliation":[{"name":"Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High 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Neurol"},{"key":"10.3233\/JAD-221258_ref16","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1002\/hbm.22157","article-title":"Distinct laterality alterations distinguish mild cognitive impairment and Alzheimer\u2019s disease from healthy aging: Statistical parametric mapping with high resolution MRI","volume":"34","author":"Long","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-221258_ref17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-221258_ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2015.07.075","article-title":"Implementation of a new parcellation of the 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