{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:11:10Z","timestamp":1777396270903,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer\u2019s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We used Automatic Segmentation of Hippocampal Subfields (ASHS) to determine MTL morphometry from MRI. We harmonized scanner effects using the recently developed longitudinal ComBat. Subjects were classified according to the A\/T\/N system, and as normal controls (NC), subjective cognitive decline (SCD), or mild cognitive impairment (MCI). Positive or negative values of A, T, and N were determined by cerebrospinal fluid measurements of the A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio, phosphorylated and total tau. From 406 included subjects, longitudinal data was available for 206 subjects by stage, and 212 subjects by A\/T\/N.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared to A\u2013\/T\u2013\/N\u2013 at baseline, the entorhinal cortex, anterior and posterior hippocampus were smaller in A+\/T+orN+. Compared to NC A\u2013 at baseline, these subregions were also smaller in MCI A+. Longitudinally, SCD A+ and MCI A+, and A+\/T\u2013\/N\u2013 and A+\/T+orN+, had significantly greater atrophy compared to controls in both anterior and posterior hippocampus. In the entorhinal and parahippocampal cortices, longitudinal atrophy was observed only in MCI A+ compared to NC A\u2013, and in A+\/T\u2013\/N\u2013 and A+\/T+orN+ compared to A\u2013\/T\u2013\/N\u2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found MTL neurodegeneration largely consistent with existing models, suggesting that harmonized MRI volumetry may be used under conditions that are common in clinical multi-center cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-221274","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T12:24:36Z","timestamp":1684844676000},"page":"259-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Medial Temporal Lobe Atrophy in Predementia Alzheimer\u2019s Disease: A Longitudinal Multi-Site Study Comparing Staging and A\/T\/N in a Clinical Research Cohort"],"prefix":"10.1177","volume":"94","author":[{"given":"Jonas Alexander","family":"Jarholm","sequence":"first","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atle","family":"Bj\u00f8rnerud","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oslo, Oslo, Norway"},{"name":"Unit for Computational Radiology and Artificial Intelligence, Oslo University hospital, Oslo, Norway"},{"name":"Department of Psychology, Faculty for Social Sciences, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turi Olene","family":"Dalaker","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stavanger Medical Imaging Laboratory, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi Sadat","family":"Akhavi","sequence":"additional","affiliation":[{"name":"Department of Technology and Innovation, The Intervention Center, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn Eivind","family":"Kirsebom","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of North Norway, Tromso, Norway"},{"name":"Department of Psychology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"P\u00e5lhaugen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaja","family":"Nordengen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f8ril Rolfseng","family":"Gr\u00f8ntvedt","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway"},{"name":"Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Nakling","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Bergen, Bergen, 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