{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:22:57Z","timestamp":1790144577586,"version":"4.0.1"},"reference-count":54,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Depression is associated with Alzheimer\u2019s disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the association between depressive symptoms and age of onset of cognitive decline in autosomal dominant AD, and to determine possible factors associated to early depressive symptoms in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study to identify depressive symptoms among 190 presenilin 1 ( PSEN1) E280A mutation carriers, subjected to comprehensive clinical evaluations in up to a 20-year longitudinal follow-up. We controlled for the following potential confounders: APOE, sex, hypothyroidism, education, marital status, residence, tobacco, alcohol, and drug abuse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PSEN1 E280A carriers with depressive symptoms before mild cognitive impairment (MCI) develop dementia faster than E280A carriers without depressive symptoms (Hazard Ratio, HR\u200a=\u200a1.95; 95% CI, 1.15\u20133.31). Not having a stable partner accelerated the onset of MCI (HR\u200a=\u200a1.60; 95 % CI, 1.03\u20132.47) and dementia (HR\u200a=\u200a1.68; 95 % CI, 1.09\u20132.60). E280A carriers with controlled hypothyroidism had later age of onset of depressive symptoms (HR\u200a=\u200a0.48; 95 % CI, 0.25\u20130.92), dementia (HR\u200a=\u200a0.43; 95 % CI, 0.21\u20130.84), and death (HR\u200a=\u200a0.35; 95 % CI, 0.13\u20130.95). APOE \u025b2 significantly affected AD progression in all stages. APOE polymorphisms were not associate to depressive symptoms. Women had a higher frequency and developed earlier depressive symptoms than men throughout the illness (HR\u200a=\u200a1.63; 95 % CI, 1.14\u20132.32).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Depressive symptoms accelerated progress and faster cognitive decline of autosomal dominant AD. Not having a stable partner and factors associated with early depressive symptoms (e.g., in females and individuals with untreated hypothyroidism), could impact prognosis, burden, and costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-221294","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T11:50:11Z","timestamp":1676980211000},"page":"911-923","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"92","author":[{"given":"Natalia","family":"Acosta-Baena","sequence":"first","affiliation":[{"name":"Grupo de Neurociencias de Antioquia (GNA), Universidad de Antioquia, Medell\u00edn, Colombia"},{"name":"Grupo de Gen\u00e9tica Molecular (GENMOL), Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Lopera-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Escuela de estad\u00edstica, Facultad de Ciencias, Universidad Nacional de Colombia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario C.","family":"Jaramillo-Elorza","sequence":"additional","affiliation":[{"name":"Escuela de estad\u00edstica, Facultad de Ciencias, Universidad Nacional de Colombia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Velilla-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia (GNA), Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Andr\u00e9s","family":"Villegas-Lanau","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia (GNA), Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Sep\u00falveda-Falla","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Arcos-Burgos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"},{"name":"Grupo GIPSI, Departamento de Psiquiatr\u00eda, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia (GNA), Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2003.39"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt26"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19444.1"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/nm1096-1146"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.010"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340027028"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70323-9"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.55403.x"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120907"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.81"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3314"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70227-2"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4907"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.177"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0611-3"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1997)10:3<186::AID-HUMU2>3.0.CO;2-H"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10636"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4851"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610203009591"},{"key":"ref021","unstructured":"World Health Organization. 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