{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:42:50Z","timestamp":1790095370138,"version":"4.0.1"},"reference-count":107,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite reports of gross motor problems in mild cognitive impairment (MCI) and Alzheimer\u2019s disease (AD), fine motor function has been relatively understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We examined if finger tapping is affected in AD, related to AD biomarkers, and able to classify MCI or AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-seven cognitively normal, 27 amnestic MCI, and 26 AD subjects completed unimanual and bimanual computerized tapping tests. We tested 1) group differences in tapping with permutation models; 2) associations between tapping and biomarkers (PET amyloid-\u03b2, hippocampal volume, and APOE \u025b4 alleles) with linear regression; and 3) the predictive value of tapping for group classification using machine learning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>AD subjects had slower reaction time and larger speed variability than controls during all tapping conditions, except for dual tapping. MCI subjects performed worse than controls on reaction time and speed variability for dual and non-dominant hand tapping. Tapping speed and variability were related to hippocampal volume, but not to amyloid-\u03b2 deposition or APOE \u025b4 alleles. Random forest classification (overall accuracy\u200a=\u200a70%) discriminated control and AD subjects, but poorly discriminated MCI from controls or AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MCI and AD are linked to more variable finger tapping with slower reaction time. Associations between finger tapping and hippocampal volume, but not amyloidosis, suggest that tapping deficits are related to neuropathology that presents later during the disease. Considering that tapping performance is able to differentiate between control and AD subjects, it can offer a cost-efficient tool for augmenting existing AD biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-221297","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:50:40Z","timestamp":1693914640000},"page":"1233-1252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Delayed and More Variable Unimanual and Bimanual Finger Tapping in Alzheimer\u2019s Disease: Associations with Biomarkers and Applications for Classification"],"prefix":"10.1177","volume":"95","author":[{"given":"Vincent","family":"Koppelmans","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Utah, Salt Lake City, UT, USA"},{"name":"Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, 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