{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:35:03Z","timestamp":1791081303136,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:p>Host responses to anti-amyloid-\u03b2 (A\u03b2) antibody therapy are evident in neuroimaging changes and clinical symptoms in a subset of clinical trial subjects receiving such therapy. The pathological basis for the imaging changes and clinical symptoms is not known, nor is the precise mechanism of A\u03b2 clearing. We report the autopsy findings in a 65-year-old woman who received three open label infusions of the experimental anti-A\u03b2 drug lecanemab over about one month. Four days after the last infusion, she was treated with tissue plasminogen activator for acute stroke symptoms and died several days later with multifocal hemorrhage. Neuropathological examination demonstrated histiocytic vasculitis involving blood vessels with cerebral amyloid angiopathy. Fragmentation and phagocytosis of vascular A\u03b2 were present throughout the cerebral cortex. Phagocytosis of parenchymal A\u03b2 plaques was noted. Changes suggestive of A\u03b2 and phosphorylated tau \u201cclearing\u201d were also noted. The findings overall suggest that anti-A\u03b2 treatment stimulated a host response to A\u03b2, i.e., target engagement. The findings also provide evidence that amyloid-related imaging abnormalities might be indicative of an A\u03b2 phagocytic syndrome within cerebral vasculature and parenchymal brain tissue in some cases.<\/jats:p>","DOI":"10.3233\/jad-221305","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:29:53Z","timestamp":1682684993000},"page":"803-813","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Neuropathology of Anti-Amyloid-\u03b2 Immunotherapy: A Case Report"],"prefix":"10.1177","volume":"93","author":[{"given":"Rudolph J.","family":"Castellani","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisheva D.","family":"Shanes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern 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