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This communication recounts the important physiological functions of amyloid-\u03b2 as a barrier protein with unique sealant and anti-pathogenic activities important for maintaining vascular integrity coupled with innate immune functions that prevent encephalitis and meningitis. The approval of a drug that obviates both of these purposive functions increases the risk of hemorrhage, edema and downstream pathogenic outcomes and should be clearly outlined to patients.<\/jats:p>","DOI":"10.3233\/jad-230040","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T11:22:20Z","timestamp":1677237740000},"page":"799-801","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Playing Russian Roulette with Alzheimer\u2019s Disease Patients: Do the Cognitive Benefits of Lecanemab Outweigh the Risk of Edema, Stroke and Encephalitis?"],"prefix":"10.1177","volume":"92","author":[{"given":"Craig S.","family":"Atwood","sequence":"first","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Development and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10388"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00206-6"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1126\/science.299.5609.1014a"},{"key":"ref005","first-page":"115","volume-title":"Functional Amyloid Aggregation","author":"Atwood CS","year":"2010"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.10.016"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1038\/nm0706-756"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70015-7"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00207"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101339"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009505"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf1059"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.043"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3040"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.103"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-143210"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106488"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04463-0"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158714"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-230040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:24Z","timestamp":1777370844000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-230040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,4,4]]}},"alternative-id":["10.3233\/JAD-230040"],"URL":"https:\/\/doi.org\/10.3233\/jad-230040","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]}}}